Bilateral ovarian masses, massive ascites, and prior appendectomy: must it be ovarian cancer? ——a case report of pseudomyxoma peritonei 24 years after appendectomy - Report - MDSpire

Bilateral ovarian masses, massive ascites, and prior appendectomy: must it be ovarian cancer? ——a case report of pseudomyxoma peritonei 24 years after appendectomy

  • By

  • Sijie Feng

  • Shurui Yang

  • Kaixuan Yang

  • Xiuzhang Yu

  • Xiaoyu Niu

  • May 22, 2026

  • 0 min

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Clinical Report: Bilateral Ovarian Masses and Significant Ascites Following Appendectomy

Overview

This case report discusses a 56-year-old female with bilateral ovarian masses and significant ascites 24 years post-appendectomy, ultimately diagnosed with pseudomyxoma peritonei (PMP). The findings emphasize the need for long-term follow-up in patients with a history of appendectomy due to the potential for late-onset PMP.

Background

Pseudomyxoma peritonei (PMP) is a rare condition characterized by the accumulation of gelatinous fluid in the peritoneal cavity, often originating from appendiceal mucinous tumors. The incidence of PMP is estimated at 2-4 cases per million annually, and its clinical presentation can mimic ovarian cancer, complicating diagnosis. Understanding the potential for PMP to develop years after appendectomy is crucial for appropriate management and follow-up.

Data Highlights

No numerical data or trial data was provided in the source material.

Key Findings

  • The patient presented with bilateral ovarian masses and massive ascites 24 years after an appendectomy.
  • Intraoperative and postoperative pathology confirmed the masses as mucinous tumors, leading to a diagnosis of PMP.
  • PMP is primarily associated with appendiceal tumors, with ovarian involvement being less common.
  • Extreme metachronous presentations of PMP, such as this case, are rare and can lead to misdiagnosis.
  • Long-term follow-up is essential for patients with a history of appendectomy to monitor for potential late-onset PMP.

Clinical Implications

Healthcare professionals should maintain a high index of suspicion for PMP in patients with a history of appendectomy presenting with abdominal distension and ovarian masses. Long-term follow-up and appropriate imaging studies are recommended for early detection of potential complications.

Conclusion

This case highlights the importance of recognizing the potential for pseudomyxoma peritonei to develop long after appendectomy, necessitating vigilant follow-up in such patients.

Related Resources & Content

  1. Frontiers in Surgery, 2026 -- Port-site metastases after diagnostic laparoscopy in advanced ovarian cancer: a case report and a systematic review of the literature
  2. Journal of Gastrointestinal Surgery, 2008 -- Appendiceal Carcinoid Tumors: A Study of 1,485 Consecutive Emergency Appendectomies
  3. Journal of Gastrointestinal Surgery, 2007 -- Retroperitoneal Perivascular Epithelioid Cell Tumor Leading to Abdominal Chyloma in a Young Female Patient
  4. BJS (British Journal of Surgery), 2023 -- Advancements in the Prevention and Management of Peritoneal Metastases Through Cytoreductive Surgery
  5. Peritoneal mesothelioma and Pseudomyxoma peritonei, 2023 -- Onkopedia Guidelines
  6. The 2022 PSOGI International Consensus on HIPEC Regimens for Peritoneal Malignancies: Pseudomyxoma Peritonei - PubMed
  7. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy to Treat Pseudomyxoma Peritonei of Ovarian Origin: A Retrospective French RENAPE Group Study - PubMed
  8. Peritoneal mesothelioma and Pseudomyxoma peritonei
  9. The 2022 PSOGI International Consensus on HIPEC Regimens for Peritoneal Malignancies: Pseudomyxoma Peritonei - PubMed
  10. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy to Treat Pseudomyxoma Peritonei of Ovarian Origin: A Retrospective French RENAPE Group Study - PubMed

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