Correction: GNPAT promotes immunosuppression in hepatocellular carcinoma by activating the plasmalogen-PPARg pathway to drive M2 macrophage polarization - Report - MDSpire

Correction: GNPAT promotes immunosuppression in hepatocellular carcinoma by activating the plasmalogen-PPARg pathway to drive M2 macrophage polarization

  • By

  • Meng Hu

  • Nan Zhang

  • Ya-Qi Wang

  • Xiao-Ming Wang

  • Yun Shi

  • Min Yao

  • Lian-Guo Hou

  • Ling-Ling Jiang

  • July 2, 2026

  • 0 min

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Correction: GNPAT facilitates immune suppression in hepatocellular carcinoma

Overview

This correction addresses errors in the original publication regarding GNPAT's role in immune suppression in hepatocellular carcinoma (HCC). The corrections pertain to Figure 3, specifically the labeling of 'PE' and the figure caption.

Background

Hepatocellular carcinoma (HCC) is a significant global health concern, characterized by immune evasion mechanisms that complicate treatment. The plasmalogen-PPARγ pathway is involved in HCC, and macrophage polarization plays a role in tumor progression.

Data Highlights

No new data is presented in the correction article.

Key Findings

  • Correction of Figure 3E from 'PE' to 'plasmalogen PE'.
  • Correction of the caption for Figure 3 from '(A, F)' to '(A). (F)'.
  • Figure 3 includes TEM images of peroxisomes in adjacent and tumor tissues.
  • Quantitative analysis of peroxisomes per field is presented in Figure 3.
  • RT-qPCR analysis of GNPAT mRNA expression levels is included in the corrected figure.

Clinical Implications

Accurate representation of data in scientific publications is essential.

Conclusion

The corrections made to the original article ensure the integrity of the research findings related to GNPAT and its role in HCC.

Related Resources & Content

  1. Hu M, Zhang N, Wang Y-Q, et al., Front. Immunol., 2026 -- Correction: GNPAT facilitates immune suppression in hepatocellular carcinoma
  2. Gastric Cancer — Alterations in PPARδ Affect the CCL20/CCR6 Pathway, Enhancing Carcinogenesis in Gastric Adenocarcinoma Through Tumor Microenvironment Remodeling
  3. Archives of Toxicology — Augmented Stimulation of Human NK Cells by Hepatocytes Exposed to Pharmaceuticals
  4. Frontiers in Immunology — Correction: MAPRE2 is associated with macrophage-enriched innate immune dysregulation and malignant phenotypes in hepatocellular carcinoma
  5. Blood Cancer Journal — High expression of PTPN21 in B-cell non-Hodgkin’s gastric lymphoma, a positive mediator of STAT5 activity
  6. EASL Clinical Practice Guidelines on the management of hepatocellular carcinoma
  7. FDA approves nivolumab with ipilimumab for unresectable or metastatic hepatocellular carcinoma
  8. GNPAT promotes immunosuppression in hepatocellular carcinoma by activating the plasmalogen-PPARγ pathway to drive M2 macrophage polarization - PMC

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