Primary aldosteronism-induced hypokalemic rhabdomyolysis syndrome: a case report and literature review - Report - MDSpire

Primary aldosteronism-induced hypokalemic rhabdomyolysis syndrome: a case report and literature review

  • By

  • Luping Cheng

  • Chuanliang Pan

  • Koushu Wang

  • Wenxin Wang

  • Xia Hu

  • Hong Wan

  • Bo Zhang

  • Ying Shu

  • June 23, 2026

  • 0 min

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Clinical Report: Rhabdomyolysis Syndrome Associated with Primary Aldosteronism

Background

Rhabdomyolysis is a serious condition that can lead to significant complications, including acute kidney injury and disseminated intravascular coagulation. Primary aldosteronism is a notable endocrine cause of hypokalemia, which can precipitate rhabdomyolysis.

Data Highlights

Case study of a 41-year-old female with rhabdomyolysis due to primary aldosteronism, presenting with elevated creatine kinase levels and hypokalemia.

Key Findings

  • Rhabdomyolysis can occur due to hypokalemia from primary aldosteronism.
  • Hypokalemia associated with primary aldosteronism is often spontaneous and refractory.
  • Rhabdomyolysis may manifest with generalized pain and weakness after minimal exertion.

Clinical Implications

Healthcare providers should consider primary aldosteronism in patients presenting with unexplained rhabdomyolysis and hypokalemia.

Conclusion

This case highlights the association between primary aldosteronism and rhabdomyolysis.

Related Resources & Content

  1. Endocrine Society, The Journal of Clinical Endocrinology & Metabolism, 2025 -- Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline
  2. Frontiers in Endocrinology, 2026 -- Case Report: Challenges in the diagnosis of pseudohypoaldosteronism: insights from a resource-limited setting
  3. Frontiers in Cardiovascular Medicine, 2026 -- Residual risk in cardiovascular and renal diseases and the potential role of aldosterone synthase inhibitors
  4. Endocrine Society, Primary Aldosteronism
  5. The Journal of Clinical Endocrinology & Metabolism — Revisiting Aldosterone Synthase Inhibitors for the Management of Cardiovascular and Renal Conditions
  6. Primary Aldosteronism | Endocrine Society
  7. A Systematic Review Supporting the Endocrine Society Clinical Practice Guideline on Management of Primary Aldosteronism
  8. Primary Aldosteronism and Hypokalemia-induced Rhabdomyolysis in a Patient with Aldosterone-producing Adenoma: A Case Report and Literature Review

Original Source(s)

Primary aldosteronism-induced hypokalemic rhabdomyolysis syndrome: a case report and literature review

  • by Luping Cheng, Chuanliang Pan, Koushu Wang, Wenxin Wang, Xia Hu, Hong Wan, Bo Zhang, Ying Shu

  • June 23, 2026

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