Clinical Report: Metagenomic and Metabolomic Analysis in Primary Aldosteronism

Overview

This study investigates the gut microbiome and metabolomic profiles in adults with primary aldosteronism (PA) and obstructive sleep apnea (OSA). Findings indicate that while global microbial diversity does not significantly vary with OSA severity, specific taxonomic and metabolic signals may reflect clinical heterogeneity.

Background

Primary aldosteronism is a common cause of secondary hypertension and is associated with increased cardiovascular risk. The coexistence of PA and obstructive sleep apnea is prevalent.

Data Highlights

No significant group-level separation in microbial gene richness or diversity was observed across OSA severity strata. Selective genera showed exploratory associations with AHI, and fecal metabolomic profiling revealed nominal phenotype-associated differences.

Key Findings

• Global gut microbial gene richness and diversity did not show strong separation across OSA severity strata.
• AHI as a continuous variable did not significantly associate with overall gene richness or alpha diversity indices.
• Exploratory associations were found between selective genera and AHI.
• Antibiotic resistance gene profiles exhibited marked inter-individual variability.
• Fecal metabolomic profiling indicated nominal differences, particularly with trehalose-related metabolites.
• No individual metabolite remained significant after global FDR correction.

Clinical Implications

The findings indicate that gut microbiome-associated heterogeneity in PA with coexisting OSA may be reflected through specific taxonomic and metabolic signals rather than overall diversity.

Conclusion

In summary, the study highlights the complexity of gut microbiome interactions in PA and OSA.

Related Resources & Content

1. European Journal of Preventive Cardiology, 2024 -- Shared genetic associations and aetiology between obstructive sleep apnoea and cardiovascular diseases: a genome-wide cross-trait analysis and bidirectional Mendelian randomization analysis
2. Endocrine Reviews, 2024 -- Subtyping of Primary Aldosteronism by Adrenal Venous Sampling
3. Frontiers in Pediatrics, 2024 -- Independent Association of Serum IgA Levels with Moderate-to-Severe Obstructive Sleep Apnea in Children with Adenotonsillar Hypertrophy
4. Clinical Research in Cardiology — Co-occurrence of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease in Patients Undergoing Percutaneous Coronary Intervention
5. Primary aldosteronism and obstructive sleep apnea: A meta-analysis of prevalence and metabolic characteristics
6. https://academic.oup.com/jcem/article/110/9/2453/8196671
7. Gut microbiota signatures in primary aldosteronism and functional identification of an aldosterone-degrading gut bacterium - PMC