Retinal connections to migraine - Report - MDSpire

Retinal connections to migraine

  • By

  • Michal Fila

  • Jan Krekora

  • Jarosław Drożdż

  • Kai Kaarniranta

  • Janusz Blasiak

  • July 2, 2026

  • 0 min

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Clinical Report: Exploring the Links Between Retinal Disorders and Migraine

Overview

This narrative review examines the associations between migraine and retinal disorders, particularly focusing on retinal migraine and age-related macular degeneration (AMD).

Background

Understanding the relationship between migraine and retinal disorders is clinically significant due to the prevalence of migraine as a disabling condition. Retinal disorders, such as AMD, can lead to irreversible vision loss.

Data Highlights

No numerical data or trial data presented in the article.

Key Findings

  • Retinal migraine is characterized by monocular visual disturbances associated with migraine headaches.
  • Photophobia and retinal artery occlusion are reported more frequently in migraine patients compared to controls.
  • Alterations in retinal nerve fiber layer thickness have been observed in migraine patients.
  • Shared mechanisms, such as microvascular dysfunction, have been proposed for both migraine and AMD.

Clinical Implications

Clinicians should be aware of the potential links between migraine and retinal disorders, particularly AMD, when assessing patients with migraine.

Conclusion

The review discusses the association between migraine and several retinal conditions, particularly AMD.

Related Resources & Content

  1. Acta Neuropathologica, Investigating the Retina's Role in Central Nervous System Disorders, 2016
  2. Frontiers in Neurology, The association between red blood cell distribution width to albumin ratio and migraine: evidence from clinical and population-based cohorts, 2026
  3. Retinal Physician, Multimodal Imaging: Redefining Retinal Disease With Current Technology, 2016
  4. Acta Neuropathologica, Deposits of α-synuclein in the retina of patients with Parkinson’s disease and corresponding animal models, 2018
  5. 1.2.4 Retinal migraine - ICHD-3, 2023
  6. Migraine as a risk factor for retinal vascular events and maculopathies: a systematic review and meta-analysis of 47 million individuals - PMC, 2023
  7. Clinical Practice Guidelines | American Headache Society, 2023
  8. 1.2.4 Retinal migraine - ICHD-3
  9. Migraine as a risk factor for retinal vascular events and maculopathies: a systematic review and meta-analysis of 47 million individuals - PMC
  10. Clinical Practice Guidelines | American Headache Society

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