Benign lesions prolapsing through the anus: a differential diagnostic algorithm and evidence-based surgical management—a narrative review - Report - MDSpire

Benign lesions prolapsing through the anus: a differential diagnostic algorithm and evidence-based surgical management—a narrative review

  • By

  • Jose Antonio Vergara Torrente

  • Luis Alfonso Huerta

  • Carlos Federico Sanchez

  • Pamela Valdez

  • Alondra Esparza González

  • Gerardo Muñoz Maldonado

  • June 11, 2026

  • 0 min

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Clinical Report: Differential Diagnosis and Surgical Approaches for Benign Anorectal Lesions

Overview

This comprehensive review addresses the diagnostic challenges of benign anorectal lesions that may prolapse through the anus, emphasizing the importance of accurate identification to avoid mismanagement of malignant conditions. A clinical decision algorithm is proposed to guide differential diagnosis and optimize surgical decision-making based on physical examination findings.

Background

Benign anorectal lesions are common in coloproctology, with a prevalence of up to 33% for certain conditions like anal condylomas. Accurate differential diagnosis is crucial to prevent delays in identifying malignant diseases and managing surgical emergencies. This review synthesizes evidence on various benign entities and proposes a structured approach to their diagnosis and treatment.

Data Highlights

No numerical data or trial data presented in the article.

Key Findings

  • Seven benign entities that may prolapse through the anus are identified: complete rectal prolapse, mucosal rectal prolapse, internal hemorrhoids, thrombosed hemorrhoids, anal condylomas, hypertrophied anal papilla, and anal canal polyps.
  • The review emphasizes the need for a thorough physical examination to differentiate between benign and malignant conditions.
  • Red flags indicating potential malignancy or surgical emergencies are highlighted for clinical awareness.
  • A clinical decision algorithm is proposed to guide the differential diagnosis based on objective clinical characteristics.
  • Therapeutic options are stratified according to the level of evidence, enhancing clinical decision-making.

Clinical Implications

Healthcare professionals should utilize the proposed clinical decision algorithm to improve the accuracy of diagnosing prolapsing anal lesions. Awareness of red flags is essential to prevent misdiagnosis and ensure timely management of potentially malignant conditions.

Conclusion

This review provides a structured approach to the differential diagnosis and management of benign anorectal lesions, underscoring the importance of clinical examination and evidence-based therapeutic strategies.

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