Severe cerebral injury secondary to an air embolism following ERCP for biliary calculus extraction: a case report - Report - MDSpire

Severe cerebral injury secondary to an air embolism following ERCP for biliary calculus extraction: a case report

  • By

  • Weimei Zhou

  • Liyang Hang

  • Guodong Wu

  • Chen Zhang

  • Xiaoyan Wang

  • Jiang Liu

  • Xuhua Cai

  • June 26, 2026

  • 0 min

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Clinical Report: Significant cerebral damage due to an air embolism after ERCP

Background

Endoscopic retrograde cholangiopancreatography (ERCP) is a critical procedure for managing biliary and pancreatic diseases, but it carries risks, including air embolism. This complication can lead to significant morbidity, including cerebral injury.

Data Highlights

No numerical data or trial data was provided in the source material.

Key Findings

  • A 70-year-old female experienced severe cerebral injury due to an air embolism during ERCP.
  • The patient exhibited decreased oxygenation and hemodynamic instability during the procedure.
  • Despite resuscitation efforts, the patient developed severe cerebral injury and ultimately had treatment withdrawn.
  • Air embolism during ERCP can result from venous entry of insufflated gas through mucosal or ductal disruption.
  • High clinical suspicion is necessary for early recognition of air embolism, with symptoms including sudden declines in end-tidal CO2 and new neurologic deficits.

Clinical Implications

Healthcare professionals performing ERCP should be aware of the risk of air embolism and monitor patients closely for signs of hemodynamic instability and neurologic changes.

Conclusion

This case emphasizes the potential severity of air embolism as a complication of ERCP.

Related Resources & Content

  1. Frontiers in Medicine, 2026 -- From shadows to light: navigating the rare complication of cerebral air embolism from a case report
  2. Intensive Care Medicine, 2021 -- Unexpected carbon dioxide embolism during laparoscopic kidney removal surgery
  3. BJS (British Journal of Surgery), 2021 -- Surgical Management of Penetrating Traumatic Brain Injury: A Case Study with Video Documentation
  4. Frontiers in Medicine, 2026 -- Case Report: Multifocal cerebral infarctions caused by cyanoacrylate glue embolization after gastric variceal injection
  5. ERCP-related adverse events: European Society of Gastrointestinal Endoscopy, 2019
  6. Gas embolism during endoscopic retrograde cholangiopancreatography: diagnosis and management - PMC
  7. Guideline ERCP-related adverse events: European So
  8. Gas embolism during endoscopic retrograde cholangiopancreatography: diagnosis and management - PMC

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