Clinical Report: Ferroptosis Mediates the Anti-Cancer Effects of Quercetin

Overview

This study investigates the role of quercetin in inducing ferroptosis in oral squamous cell carcinoma (OSCC) cells through the LGR4/NF-κB/GPX4 pathway. Quercetin demonstrated a dose-dependent reduction in OSCC cell viability.

Background

Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with poor prognosis due to chemotherapy resistance and severe side effects. Understanding the mechanisms of compounds like quercetin that can induce ferroptosis may provide new avenues for OSCC treatment.

Data Highlights

Key Findings

• Quercetin induces ferroptosis in OSCC cells.
• Co-treatment with liproxstatin-1 inhibits quercetin's effects.
• Quercetin reduces GPX4 expression by inhibiting the LGR4/NF-κB pathway.
• LGR4 activation promotes NF-κB signaling, contributing to OSCC cell survival.
• Ferroptosis may play a significant role in quercetin's anti-OSCC activity.

Clinical Implications

Further exploration of the LGR4/NF-κB/GPX4 pathway may enhance therapeutic strategies against OSCC.

Conclusion

Quercetin's ability to induce ferroptosis through the LGR4/NF-κB/GPX4 pathway presents findings that warrant further research.

Related Resources & Content

1. Author(s)/Org, Source, Year -- Ferroptosis Mediates the Anti-Cancer Effects of Quercetin
2. Author(s)/Org, Source, Year -- From molecular crosstalk to precision therapy: targeting ferroptosis and cuproptosis in oral squamous cell carcinoma
3. Author(s)/Org, Source, Year -- A ferroptosis-related lncRNAs risk score model identifies LINC02178 as a potential regulator of ferroptosis sensitivity in cervical cancer
4. Author(s)/Org, Source, Year -- LF3 exerts anti-osteosarcoma effects through Wnt signaling inhibition-coupled ferroptosis induction via HO-1/ACSL4 axis
5. Frontiers in Oncology — Quercetagetin-rich flavonoids from marigold induce apoptosis inhibit metastasis of non-small cell lung cancer via the p53/p21 signaling pathway
6. SEOM–TTCC clinical guidelines for the treatment of head and neck cancer (2025)
7. Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer
8. Ferroptosis and head and neck cancer: Mechanisms and therapeutic perspectives (Review)