Clinical Report: Admission-Based Inflammatory Indices and In-Hospital Mortality

Overview

This study evaluates the association of admission-based inflammatory indices, including the C-reactive protein-to-albumin ratio (CAR), with in-hospital mortality in ICU patients.

Background

Accurate risk stratification in emergency departments is crucial for identifying critically ill patients who may require ICU admission. Systemic inflammation is common in these patients, and traditional markers may not fully capture their complex inflammatory and nutritional status.

Data Highlights

Key Findings

• Non-survivors had significantly higher median MII values and CAR levels compared to survivors (p < 0.001).
• All three MII variants and CAR were associated with in-hospital mortality in age- and sex-adjusted analyses.
• CAR demonstrated the most consistent association with mortality across various analyses.
• Discriminative performance of the indices was modest, with CAR showing the highest AUC of 0.627.

Clinical Implications

Clinicians should consider the use of CAR and MII variants as supplementary markers for assessing the inflammatory burden in critically ill patients. However, reliance on these indices alone for prognostication may not be sufficient due to their limited discriminatory performance.

Conclusion

The study highlights the association of admission-based inflammatory indices with in-hospital mortality.

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