Immunogenetic HLA-DQ and IgG serological profiles in individuals with self-reported wheat/gluten sensitivity: a retrospective real-world evidence study - Report - MDSpire

Immunogenetic HLA-DQ and IgG serological profiles in individuals with self-reported wheat/gluten sensitivity: a retrospective real-world evidence study

  • By

  • Andreina White

  • Julie Verzura

  • Mariana White

  • Carol Rodríguez

  • Mercedes White

  • Milaidi García Bravo

  • May 25, 2026

  • 0 min

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Clinical Report: Immunogenetic and Serological Profiles in Wheat Sensitivity

Overview

{'clarification': 'Specify if 100% prevalence refers to cumulative or individual variants.'}

Background

The increasing prevalence of self-reported wheat/gluten sensitivity highlights the need for better understanding and management of this condition, which affects 5-15% of the global population. Current diagnostic frameworks lack validated biomarkers for non-celiac gluten sensitivity, making it essential to explore genetic and immunological profiles in symptomatic individuals. This study aims to fill that gap by characterizing the biological profiles of patients seeking clinical management for wheat/gluten-related discomfort.

Data Highlights

{'alignment': 'Ensure data aligns with statistical methods and clarify Odds Ratio context.'}

Key Findings

{'details': 'Include p-values for all significant findings.'}

Clinical Implications

{'expansion': 'Provide examples of how IgG testing can be used in practice.'}

Conclusion

{'enhancement': 'List specific areas for further research.'}

Related Resources & Content

  1. Journal of Gastroenterology, 2013 -- Serum Celiac Antibody Prevalence Among IBD Patients in Japan
  2. Journal of Gastroenterology, 2016 -- Sustained Improvement on a Gluten-Free Diet Suggests Non-Celiac Wheat Sensitivity
  3. The New Gastroenterologist, 2023 -- Celiac Disease: Recent Advances in Diagnosis and Patient Monitoring
  4. Journal of Gastroenterology, 2017 -- Detecting Celiac Disease in Asymptomatic Pediatric Patients
  5. ACG Guideline, 2023 -- Diagnosis and Management of Celiac Disease
  6. ACG Celiac Disease Guidelines
  7. Effect of Expectancy vs Actual Gluten Intake on Symptoms
  8. ACG Guideline: Diagnosis and Management of Celiac Disease - PubMed

Original Source(s)

Immunogenetic HLA-DQ and IgG serological profiles in individuals with self-reported wheat/gluten sensitivity: a retrospective real-world evidence study

  • by Andreina White, Julie Verzura, Mariana White, Carol Rodríguez, Mercedes White, Milaidi García Bravo

  • May 25, 2026

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