Retraction Note: Hydroxyethylstarch as a Risk Factor for Acute Renal Failure - Report - MDSpire

Retraction Note: Hydroxyethylstarch as a Risk Factor for Acute Renal Failure

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  • Joachim Boldt

  • July 9, 2026

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Withdrawal Notice: Hydroxyethylstarch Linked to Increased Risk of Acute Kidney Injury

Overview

The article has been retracted due to concerns regarding ethical approval and data reliability.

Background

Hydroxyethyl starch (HES) has been widely used in various clinical scenarios to treat hypovolemia. Recent regulatory actions and studies have raised concerns about the safety of HES, particularly regarding acute kidney injury (AKI) associated with its use.

Data Highlights

No numerical data is available due to the retraction of the article.

Key Findings

  • The article has been retracted due to ethical and data concerns.
  • Regulatory bodies, including the EMA and FDA, have issued warnings regarding the use of HES.
  • Guidelines recommend against the use of HES in patients with sepsis or septic shock.

Clinical Implications

Healthcare professionals should be aware of the retraction and the associated risks of HES.

Conclusion

The article has been retracted due to concerns regarding ethical approval and data reliability.

Related Resources & Content

  1. Drug Safety, 2002 -- Withdrawal Notice: Hydroxyethylstarch Linked to Increased Risk of Acute Kidney Injury
  2. Assessment of Renal Safety for Hydroxyethyl Starch 130/0.42 Following Cardiac Surgery, Drug Safety, 2021
  3. Is the Evidence Regarding the Risks of HES Ambiguous? The Answer is No, Intensive Care Medicine, 2016
  4. Strategies for Preventing Acute Kidney Injury and Preserving Renal Function in Intensive Care Settings: A 2017 Update, Intensive Care Medicine, 2017
  5. Hydroxyethyl-starch solutions for infusion recommended for suspension from the market, European Medicines Agency (EMA), 2022
  6. Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis, New England Journal of Medicine, 2012
  7. Intensive Care Medicine — Amendment to: The Presence of Hydroxyethyl Starch in Tissues of Humans and Animals: A Comprehensive Review
  8. Hydroxyethyl-starch solutions for infusion recommended for suspension from the market | European Medicines Agency (EMA)
  9. Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis | New England Journal of Medicine

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