Clinical Report: Relationship Between Triglyceride-Glucose Index and Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes Mellitus
Overview
This study investigates the association between the triglyceride-glucose (TyG) index and cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM). It finds that a higher TyG index correlates with increased prevalence of CAN.
Background
Cardiovascular autonomic neuropathy (CAN) is a common yet often underdiagnosed complication of diabetes, linked to increased cardiovascular risk. The triglyceride-glucose (TyG) index is a marker of insulin resistance.
Data Highlights
Parameter
Value
Prevalence of CAN
61.3%
AUC for TyG index
0.854 (95% CI: 0.796–0.911)
Key Findings
The prevalence of CAN in the study cohort was 61.3%.
Patients with CAN had a significantly higher TyG index compared to those without CAN.
The TyG index positively correlated with CART parameters, including E:I difference and Valsalva ratio.
Inverse correlations were found between the TyG index and various HRV indices, indicating reduced heart rate variability.
After adjusting for confounders, the TyG index remained a significant independent predictor of CAN.
ROC curve analysis indicated favorable discriminatory power of the TyG index for CAN.
Clinical Implications
The findings indicate a relationship between the TyG index and CAN.
Conclusion
The study highlights the association between the TyG index and cardiovascular autonomic neuropathy.
