Lung- and diaphragm-protective mechanical ventilation in acute respiratory distress syndrome - Report - MDSpire

Lung- and diaphragm-protective mechanical ventilation in acute respiratory distress syndrome

  • By

  • Glauco M. Plens

  • Idunn S. Morris

  • Richard Greendyk

  • Andrea Castellví-Font

  • Annemijn H. Jonkman

  • Domenico L. Grieco

  • Glasiele C. Alcala

  • Jose Dianti

  • Marcelo Britto Passos Amato

  • Martin Dres

  • Shailesh Bihari

  • Robinder G. Khemani

  • Laurent Brochard

  • Taiga Itagaki

  • Ewan C. Goligher

  • July 7, 2026

  • 0 min

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Protective Mechanical Ventilation Strategies for the Lungs and Diaphragm in ARDS

Background

Acute respiratory distress syndrome (ARDS) is associated with high mortality rates. Mechanical ventilation is crucial in managing ARDS, but it can lead to complications such as ventilator-induced lung injury (VILI) and diaphragm dysfunction. Understanding the mechanisms of injury and developing protective strategies is essential for improving patient care.

Data Highlights

No numerical data or trial results were provided in the source material.

Key Findings

  • Mechanical ventilation can cause both lung and diaphragm injury, increasing morbidity and mortality in ARDS patients.
  • Excessive respiratory effort can exacerbate lung injury through mechanisms such as cyclic overdistension and increased pleural pressure swings.
  • Diaphragm inactivity during mechanical ventilation can lead to atelectasis and further lung injury.
  • Emerging strategies focus on lung- and diaphragm-protective ventilation to limit the adverse effects of mechanical ventilation.
  • Timely restoration of spontaneous breathing may help protect lung function if respiratory effort is controlled.

Clinical Implications

Clinicians should be aware of the risks associated with mechanical ventilation in ARDS, particularly the impact of respiratory effort on lung and diaphragm injury.

Conclusion

Protective mechanical ventilation strategies aim to reduce the risk of lung and diaphragm injury.

Related Resources & Content

  1. Critical Care (Springer), 2025 -- Lung-protective ventilation strategy in acute respiratory distress syndrome: a critical reappraisal of current practice
  2. Intensive Care Medicine, 2026 -- The emerging role of diaphragm neurostimulation in ARDS
  3. Intensive Care Medicine, 2020 -- Approaches to Implement Lung and Diaphragm-Guarding Ventilation: Preventing Inadequate and Excessive Effort
  4. Critical Care (Springer), 2025 -- Driving pressure-limited ventilation strategies versus conventional lung protective ventilation strategies for patients with ARDS/ARF: a systematic review and meta-analysis of randomized controlled trials
  5. Effect of a driving pressure-limiting strategy for patients with acute respiratory distress syndrome secondary to community-acquired pneumonia: the STAMINA randomised clinical trial - PMC
  6. Continuous and noninvasive respiratory effort monitoring: a narrative review of emerging techniques | Journal of Intensive Care | Springer Nature Link
  7. https://karger.com/res/article-pdf/doi/10.1159/000549732/4480471/000549732.pdf
  8. Effect of a driving pressure-limiting strategy for patients with acute respiratory distress syndrome secondary to community-acquired pneumonia: the STAMINA randomised clinical trial - PMC
  9. Continuous and noninvasive respiratory effort monitoring: a narrative review of emerging techniques | Journal of Intensive Care | Springer Nature Link

Original Source(s)

Lung- and diaphragm-protective mechanical ventilation in acute respiratory distress syndrome

  • by Glauco M. Plens, Idunn S. Morris, Richard Greendyk, Andrea Castellví-Font, Annemijn H. Jonkman, Domenico L. Grieco, Glasiele C. Alcala, Jose Dianti, Marcelo Britto Passos Amato, Martin Dres, Shailesh Bihari, Robinder G. Khemani, Laurent Brochard, Taiga Itagaki, Ewan C. Goligher

  • July 7, 2026

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