Adipokine profiles and genetic variants of leptin receptor, adiponectin, and ghrelin pathways in obesity: prospective 12-month outcomes after bariatric interventions - Report - MDSpire

Adipokine profiles and genetic variants of leptin receptor, adiponectin, and ghrelin pathways in obesity: prospective 12-month outcomes after bariatric interventions

  • By

  • Andriy Prodan

  • Ihor Dzyubanovsky

  • Iryna Halabitska

  • Pavlo Petakh

  • Iryna Kamyshna

  • Oleksandr Kamyshnyi

  • May 20, 2026

  • 0 min

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Clinical Report: Genetic Variants and Adipokine Levels in Obesity

Overview

This study investigates the relationship between genetic polymorphisms, adipokine levels, and clinical indicators in obese patients undergoing bariatric surgery. Key findings indicate that specific genetic variants influence hormonal profiles and weight loss outcomes post-surgery.

Background

Obesity is a significant risk factor for metabolic disorders, including type 2 diabetes and cardiovascular disease. Understanding the genetic and hormonal factors involved in obesity can help tailor treatment strategies. This study highlights the role of adipokines and genetic variants in obesity management, particularly following bariatric interventions.

Data Highlights

{'p-value_format': 'Ensure all p-values are consistently formatted.'}

Key Findings

{'details': 'Add more context on the implications of the genetic variants.'}

Clinical Implications

{'integration': 'Suggest specific ways to implement genetic testing in treatment plans.'}

Conclusion

The study underscores the importance of genetic and hormonal factors in obesity treatment, particularly after bariatric surgery. Tailoring interventions based on these factors may enhance patient outcomes.

Related Resources & Content

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  5. American Diabetes Association, Diabetes Care, 2025 -- Obesity and Weight Management for the Prevention and Treatment of Type 2 Diabetes: Standards of Care in Diabetes–2025
  6. Magnitude and Durability of Hormonal Adaptations After Bariatric Surgery: A Dose Response Meta-Analysis, ScienceDirect
  7. Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery, PubMed
  8. 8. Obesity and Weight Management for the Prevention and Treatment of Type 2 Diabetes: Standards of Care in Diabetes–2025 | Diabetes Care | American Diabetes Association
  9. Magnitude and Durability of Hormonal Adaptations After Bariatric Surgery: A Dose Response Meta-Analysis - ScienceDirect
  10. Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery - PubMed

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