Impact of the Triglyceride-Glucose Index on Prognosis Following Endovascular Therapy for Acute Ischemic Stroke: Effect Modification by Collateral Circulation - Report - MDSpire
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Impact of the Triglyceride-Glucose Index on Prognosis Following Endovascular Therapy for Acute Ischemic Stroke: Effect Modification by Collateral Circulation
Influence of the Triglyceride-Glucose Index on Outcomes After Endovascular Treatment for Acute Ischemic Stroke
Overview
This study investigates the association between the triglyceride-glucose (TyG) index and 90-day functional outcomes in patients with acute ischemic stroke undergoing endovascular therapy. The findings suggest that the TyG index is an independent risk factor for poor outcomes, with collateral circulation playing a modifying role in this association.
Background
Acute ischemic stroke is a leading cause of morbidity and mortality, and effective risk stratification is crucial for optimizing patient management. The TyG index serves as a simple marker for insulin resistance, which has been linked to adverse vascular outcomes. Understanding its role in predicting functional outcomes post-endovascular therapy can enhance clinical decision-making.
Data Highlights
Outcome
Group
Count
Good Functional Outcome (mRS ≤ 2)
TyG Index
145 (69.4%)
Poor Functional Outcome (mRS > 2)
TyG Index
64 (30.6%)
Key Findings
The TyG index was significantly higher in the poor functional outcome group (p < 0.05).
Multivariable logistic regression indicated that the TyG index is independently associated with poor functional outcomes (OR = 1.972, p < 0.001).
Collateral circulation status significantly modified the association between the TyG index and outcomes (p = 0.012).
The combined risk assessment model incorporating the TyG index demonstrated good discriminative ability (AUC = 0.834).
Stratified analysis revealed a more pronounced association in patients with poor collateral circulation.
Clinical Implications
The TyG index can be utilized as a practical tool for early risk stratification in patients with acute ischemic stroke undergoing endovascular therapy. Clinicians should consider collateral circulation status when interpreting TyG index results to better predict patient outcomes.
Conclusion
The TyG index is a valuable independent predictor of functional outcomes after endovascular therapy for acute ischemic stroke, with collateral circulation serving as a significant modifier of this relationship.
