Correction: A mechanistic vascular model for dysregulation of the pre-neoplastic microenvironment and the onset of early carcinogenesis

Overview

This correction addresses the omission of the abstract in the original publication, which outlines a mechanovascular framework linking chronic vasomotor dysregulation and metabolic changes to early carcinogenesis.

Background

Understanding the mechanisms underlying early carcinogenesis is crucial. The interplay between vascular dysregulation and metabolic reprogramming may contribute to the establishment of a pre-neoplastic microenvironment.

Data Highlights

No numerical or trial data provided in the source material.

Key Findings

• Aerobic glycolysis is a key feature of many solid tumors, initiated by chronic vasomotor dysregulation.
• Endothelial glycocalyx disruption and low-grade inflammation contribute to elevated interstitial fluid pressure.
• Impaired lymphatic drainage and endothelial hyperpermeability are associated with extracellular matrix remodeling.
• Functional hypoxia may result from spatial dysregulation of oxygen delivery rather than vascular insufficiency.
• Elevated extracellular lactate levels can impair immune cell function.

Clinical Implications

Restoring vascular-interstitial homeostasis may be a strategy for intercepting early cancer development.

Conclusion

This correction emphasizes the mechanovascular framework in understanding early carcinogenesis.

Related Resources & Content

1. Vayakkattil AB, Pazhanchery AS, Vijayarajan V, Vayakkattil U, Front. Oncol., 2026 -- Correction: A mechanistic vascular model for dysregulation of the pre-neoplastic microenvironment and the onset of early carcinogenesis
2. Frontiers in Cardiovascular Medicine — Mechanopriming by vascular stiffness and phenotypic reprogramming by disturbed flow: mechanobiology and clinical translation in atherosclerosis
3. Acta Neuropathologica — Reassessing Tumor Angiogenesis and Anti-Angiogenic Treatments in Malignant Gliomas
4. Frontiers in Cardiovascular Medicine — Mechanisms of vascular calcification: cellular phenotype switching drives matrix remodeling and mineralized microenvironment formation
5. Frontiers in Oncology — VANGL1 links angiogenesis–stemness programs and tumor microenvironment remodeling: a pan-cancer, multi-omics study with translational validation
6. Targeting angiogenesis: Lessons from 25 years of normalizing tumor vasculature
7. Colorectal cancer screening guideline update 2026
8. Aspirin May Reduce Risk of Colorectal Cancer Recurrence for Some Patients - ASCO