Osteoporosis Linked to Increased Dry AMD Risk

Genetic and pooled observational data suggest a unidirectional association, with elevated odds of dry age-related macular degeneration and a stronger signal in women.

By
Julie Greenbaum
February 24, 2026
3 min

MDSpire News

Overview

A meta-analysis and Mendelian randomization study found that osteoporosis is associated with increased odds of dry age-related macular degeneration (AMD) in women, with no significant association found in men.

Background

Osteoporosis is a common condition characterized by decreased bone density, which can lead to fractures and other complications. Understanding its association with age-related macular degeneration is crucial, as AMD is a leading cause of vision loss in older adults. Identifying risk factors for AMD can help in early detection and management strategies.

Data Highlights

Study Type	Findings
Meta-analysis	1.5 times the odds of overall AMD in women
Early AMD	1.6 times the odds in women
Advanced AMD	No significant association in women
Mendelian Randomization	1.3 times the odds of dry AMD

Key Findings

Osteoporosis is associated with 1.5 times the odds of overall AMD in women.
Osteoporosis is linked to 1.6 times the odds of early AMD in women.
No significant association between osteoporosis and AMD was found in men.
Genetically predicted osteoporosis was associated with 1.3 times the odds of dry AMD.
Reverse Mendelian randomization did not indicate AMD causing osteoporosis.
Only the osteoporosis-to-dry AMD association met the adjusted significance threshold after Bonferroni correction.

Clinical Implications

Healthcare providers should consider osteoporosis as a potential risk factor for dry AMD, particularly in elderly women, while also being aware of its implications in men. Early screening and monitoring for AMD in patients with osteoporosis may improve outcomes and facilitate timely interventions.

Conclusion

The findings suggest a unidirectional causal relationship from osteoporosis to dry AMD in women, highlighting the need for increased awareness and preventive strategies in at-risk populations.