Personalized management of glucokinase-related monogenic diabetes (GCK-MODY) during pregnancy: a case report - Report - MDSpire

Personalized management of glucokinase-related monogenic diabetes (GCK-MODY) during pregnancy: a case report

  • By

  • Ana Filipa Bolas

  • João Oliveira Torres

  • Paula Bogalho

  • José Silva-Nunes

  • May 28, 2026

  • 0 min

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Clinical Report: Tailored Approach to Managing GCK-MODY in Pregnancy

Overview

This case study presents the management of a 33-year-old woman with glucokinase-related monogenic diabetes (GCK-MODY) during pregnancy. The patient achieved adequate glycemic control through a tailored insulin regimen and continuous glucose monitoring despite a variant of uncertain significance.

Background

GCK-MODY is a form of monogenic diabetes characterized by stable, mild fasting hyperglycemia and typically does not require pharmacologic therapy outside of pregnancy. Management during pregnancy is critical as maternal glycemia can significantly affect fetal growth, especially when the fetal genotype is unknown. Understanding the unique treatment needs during pregnancy is essential for optimizing outcomes for both mother and child.

Data Highlights

No numerical data provided in the article.

Key Findings

  • The patient was diagnosed with diabetes at age 9 and had a family history of diabetes, including confirmed GCK-MODY.
  • Genetic testing identified a heterozygous variant in the GCK gene classified as of uncertain significance.
  • During pregnancy, the patient required initiation of basal insulin therapy and ultimately progressed to a basal-bolus regimen.
  • Continuous glucose monitoring was implemented to optimize metabolic control.
  • The patient delivered a healthy male newborn at 36 weeks and 2 days with an appropriate APGAR score.

Clinical Implications

This case emphasizes the importance of individualized insulin therapy guided by continuous glucose monitoring in managing GCK-MODY during pregnancy. Clinicians should consider the implications of genetic variants and the absence of fetal genotyping when developing treatment plans.

Conclusion

Revise to reflect only conclusions drawn from the case report without additional interpretations.

Related Resources & Content

  1. Frontiers in Endocrinology, 2026 -- Case Report: A novel likely pathogenic GCK variant in a young Chinese girl with severe insulin resistance
  2. The Journal of Clinical Endocrinology & Metabolism, 2025 -- Variability in Gestational Diabetes and Its Association with Negative Pregnancy Outcomes: Findings from a Cohort Analysis
  3. The Journal of Clinical Endocrinology & Metabolism, 2025 -- Utilizing Diabetes Technology for Managing Pregnant Patients with Diabetes
  4. The Journal of Clinical Endocrinology & Metabolism, 2025 -- Guidelines for Managing Preexisting Diabetes During Pregnancy: A Collaborative Approach by the Endocrine Society and European Society of Endocrinology
  5. Diagnosis and Clinical Management of Monogenic Diabetes - Endotext - NCBI Bookshelf
  6. Frontiers | Enhancing fetal outcomes in GCK-MODY pregnancies: a precision medicine approach via non-invasive prenatal GCK mutation detection
  7. Diagnosis and Clinical Management of Monogenic Diabetes - Endotext - NCBI Bookshelf
  8. Frontiers | Enhancing fetal outcomes in GCK-MODY pregnancies: a precision medicine approach via non-invasive prenatal GCK mutation detection

Original Source(s)

Personalized management of glucokinase-related monogenic diabetes (GCK-MODY) during pregnancy: a case report

  • by Ana Filipa Bolas, João Oliveira Torres, Paula Bogalho, José Silva-Nunes

  • May 28, 2026

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