The Clinical Value of Endoscopic Ultrasonography Combined with Endoscopic Treatment for Upper Gastrointestinal Lifting Lesions - Report - MDSpire

The Clinical Value of Endoscopic Ultrasonography Combined with Endoscopic Treatment for Upper Gastrointestinal Lifting Lesions

  • By

  • Guo, Huanhuan

  • Peng, Bo

  • Xiong, Zhang'e

  • Li, Ziyin

  • April 9, 2026

  • 0 min

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Clinical Report: Evaluating the Combined Effectiveness of EUS and Endoscopic Therapy

Overview

This study assesses the effectiveness of endoscopic ultrasonography (EUS) combined with endoscopic intervention for protruding upper gastrointestinal lesions. The findings indicate a high success rate for endoscopic management and a strong diagnostic concordance between EUS and pathological diagnoses.

Background

Upper gastrointestinal lesions, particularly those that protrude, pose significant diagnostic and therapeutic challenges. Accurate identification and management of these lesions are crucial to prevent complications and ensure effective treatment. The integration of EUS with endoscopic therapy may enhance diagnostic accuracy and treatment outcomes.

Data Highlights

ParameterValue
Total Cases106
Successful Endoscopic Management101
Surgical Interventions5
Diagnostic Concordance Rate81.13%
Concordance for Polyps89.66%
Concordance for Leiomyomas86.36%
Concordance for GIST73.33%

Key Findings

  • Endoscopic management was successful in 101 out of 106 cases.
  • The diagnostic concordance rate between EUS and pathological diagnosis was 81.13%.
  • Concordance rates for specific lesion types were 89.66% for polyps, 86.36% for leiomyomas, and 73.33% for GIST.
  • EUS demonstrated high sensitivity and specificity for polyps (92.86%/98.04%), leiomyomas (88.00%/97.06%), and GIST (73.33%/98.99%).
  • Endoscopic treatments based on EUS evaluations were clinically safe with low postoperative complications.
  • There is a need for improved clinical expertise for less common GI conditions to reduce misdiagnosis risks.

Clinical Implications

The study highlights the importance of EUS in accurately diagnosing and managing protruding upper GI lesions. Clinicians should consider utilizing EUS as a standard practice to enhance treatment efficacy and minimize complications.

Conclusion

The findings support the use of EUS in the management of upper GI protruding lesions, demonstrating its diagnostic accuracy and safety in endoscopic interventions. Future studies should address the limitations of this research to further validate these results.

References

  1. Surgical Endoscopy, 2024 -- Assessing the Safety and Effectiveness of Submucosal Tunneling Endoscopic Resection for Large Esophageal Subepithelial Lesions
  2. Surgical Endoscopy, 2024 -- Comparative Efficacy of Various Resolution Endoscopy Techniques for Identifying Mucosal Lesions in the Upper Gastrointestinal Tract
  3. Techniques in Coloproctology, 2025 -- Management Strategies for Giant Colorectal Lesions Exhibiting Muscle Retracting Sign (MRS+)
  4. Journal of Gastrointestinal Surgery, 2023 -- Endorectal Ultrasound (ERUS): A Precise and Essential Method for Selecting Candidates for Transanal Excision/Transanal Endoscopic Microsurgery
  5. ESGE Guidelines, 2025 -- Technical and Technology Review
  6. Endoscopic resection for gastric subepithelial tumours: a retrospective cohort study
  7. Controversies in NEN, 2023 -- An ENETS position statement on the endoscopic management of localised gastric, duodenal and rectal neuroendocrine neoplasms
  8. ESGE Guidelines 2025
  9. Endoscopic resection for gastric subepithelial tumours: a retrospective cohort study - PubMed
  10. Controversies in NEN: An ENETS position statement on the endoscopic management of localised gastric, duodenal and rectal neuroendocrine neoplasms - PMC

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