Age- and sex-based risk stratification in takotsubo syndrome: a Japanese nationwide registry study - Report - MDSpire

Age- and sex-based risk stratification in takotsubo syndrome: a Japanese nationwide registry study

  • By

  • Tomohiro Hayashi

  • Kazuaki Negishi

  • Takato Kobayashi

  • Koshiro Kanaoka

  • Hozuka Akita

  • Yuto Shinkura

  • Ryo Nishio

  • Kensuke Matsumoto

  • Masahiko Hoshijima

  • Satoru Kawasaki

  • Hogara Nishisaki

  • Masanobu Okayama

  • Tsuneaki Kenzaka

  • July 1, 2026

  • 0 min

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Clinical Report: Risk Assessment in Takotsubo Syndrome Based on Age and Gender

Overview

This study analyzes age- and sex-specific differences in clinical characteristics and outcomes of Takotsubo syndrome (TTS) using a nationwide Japanese registry. It identifies older age and male sex as predictors of in-hospital mortality.

Background

Takotsubo syndrome (TTS) is an acute cardiac dysfunction often triggered by stress, predominantly affecting older postmenopausal women. Understanding the impact of age and sex on TTS outcomes is crucial for risk assessment and management. This study addresses the limited data on male patients.

Data Highlights

Age GroupIn-Hospital Mortality (Men)In-Hospital Mortality (Women)
≤50 years3.0%1.5%
51–74 years4.3%1.5%
≥75 years8.2%4.6%

Key Findings

  • Among 13,585 patients, 18.8% were men.
  • Men had higher rates of comorbidities and required more intensive care than women.
  • In-hospital mortality increased with age in both sexes.
  • Older age (OR 1.32 per 5 years) and male sex (OR 1.59) were independent predictors of in-hospital mortality.
  • Adverse events were more frequent in older patients across both sexes.

Clinical Implications

Clinicians should consider age and sex when assessing the risk of in-hospital mortality in TTS patients.

Conclusion

This study highlights the importance of age and sex in predicting in-hospital mortality in TTS.

Related Resources & Content

  1. Frontiers | Age- and sex-based risk stratification in takotsubo syndrome: a Japanese nationwide registry study
  2. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes - American College of Cardiology
  3. Comparative Analysis of Takotsubo Syndrome Across Ethnic Groups: New Findings from the International Takotsubo Registry
  4. Psychological Impact of SARS-CoV-2 Infection Leading to Takotsubo Cardiomyopathy
  5. Evaluation of Coronary Microvascular Dysfunction in Takotsubo Syndrome Through Angiography-Based Microcirculatory Resistance Index Analysis
  6. Acta Neurochirurgica — Pressor use and its impact on outcomes in aneurysmal subarachnoid hemorrhage patients with takotsubo cardiomyopathy: a quantitative analysis
  7. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes - American College of Cardiology
  8. Frontiers | Age- and sex-based risk stratification in takotsubo syndrome: a Japanese nationwide registry study
  9. Cardiogenic Shock Complicating Takotsubo Syndrome: Sex‐Related Differences - PMC
  10. Sex-based Disparities In Clinical Outcomes Of Takotsubo Syndrome With Cardiogenic Shock: Insights From A Large Healthcare Database - ScienceDirect

Original Source(s)

Age- and sex-based risk stratification in takotsubo syndrome: a Japanese nationwide registry study

  • by Tomohiro Hayashi, Kazuaki Negishi, Takato Kobayashi, Koshiro Kanaoka, Hozuka Akita, Yuto Shinkura, Ryo Nishio, Kensuke Matsumoto, Masahiko Hoshijima, Satoru Kawasaki, Hogara Nishisaki, Masanobu Okayama, Tsuneaki Kenzaka

  • July 1, 2026

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