Aegeline mitigates isoproterenol-induced myocardial infarction: insights from biochemical, histopathological, and in silico studies - Report - MDSpire

Aegeline Reduces Myocardial Infarction Induced by Isoproterenol: Findings from Biochemical, Histopathological, and In Silico Analyses

  • By

  • Sami I. Alzarea

  • Muhammad Afzal

  • Misbahuddin Rafeeq

  • Alaa Hamed Habib

  • Tariq G. Alsahli

  • Omar Awad Alsaidan

  • Hassan H. Alhassan

  • Abdulaziz Ibrahim Alzarea

  • Aseel Awad Alsaidan

  • Nadeem Sayyed

  • Imran Kazmi

  • July 21, 2026

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Clinical Report: Aegeline Reduces Myocardial Infarction Induced by Isoproterenol

Overview

This study investigates the cardioprotective effects of aegeline against myocardial infarction induced by isoproterenol in experimental rats. Aegeline demonstrated improvements in histopathological features and biochemical markers of myocardial injury.

Background

Myocardial infarction (MI) is a leading cause of morbidity and mortality globally. Natural products, such as aegeline from Aegle marmelos, are being explored for their pharmacological activities.

Data Highlights

ParameterEffect of Aegeline
Histopathological FeaturesImprovement
Myocardial DamageReduction
Oxidative Stress MarkersImprovement
Inflammatory IndicatorsReduction
Apoptotic ExpressionInhibition

Key Findings

  • Aegeline exhibited cardioprotective properties against isoproterenol-induced myocardial damage.
  • Histopathological features improved with aegeline treatment.
  • Aegeline reduced oxidative stress and inflammatory markers in myocardial injury.
  • Molecular docking studies indicated binding affinity of aegeline for CK-MB.
  • Aegeline did not adversely affect liver or kidney function.

Clinical Implications

Further research is warranted to explore the mechanisms of action of aegeline in human subjects.

Conclusion

Aegeline demonstrates cardioprotective effects in experimental myocardial injury.

Related Resources & Content

  1. Basic Research in Cardiology, 2012 -- The Secretome from Apoptotic Peripheral Blood Cells (APOSEC) Reduces Microvascular Obstruction in a Porcine Model of Reperfused Acute Myocardial Infarction: Implications for Platelet Aggregation and Vasodilation
  2. Basic Research in Cardiology, 2011 -- The Secretome of Apoptotic Peripheral Blood Cells (APOSEC) Provides Cytoprotection to Cardiomyocytes and Reduces Tissue Remodeling Following Acute Myocardial Infarction: A Preclinical Investigation
  3. Basic Research in Cardiology, 2024 -- Enhanced β3-Adrenergic Receptor Expression in Cardiomyocytes Prepares Mitochondria for Resilience Against Ischemia-Reperfusion Injury
  4. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes
  5. Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction - PubMed
  6. Basic Research in Cardiology — Metoprolol Pretreatment Fails to Significantly Decrease Infarct Size and No-Reflow in Adult Göttingen Minipigs
  7. Effects of supersaturated oxygen therapy on infarct size and microvascular obstruction following myocardial infarction: A systematic review and meta-analysis
  8. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
  9. Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction - PubMed

Original Source(s)

Aegeline mitigates isoproterenol-induced myocardial infarction: insights from biochemical, histopathological, and in silico studies

  • by Sami I. Alzarea, Muhammad Afzal, Misbahuddin Rafeeq, Alaa Hamed Habib, Tariq G. Alsahli, Omar Awad Alsaidan, Hassan H. Alhassan, Abdulaziz Ibrahim Alzarea, Aseel Awad Alsaidan, Nadeem Sayyed, Imran Kazmi

  • July 21, 2026

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