Nonlinear relationship and threshold effect of D-dimer on preoperative deep vein thrombosis in patients with ankle fractures: a retrospective study - Report - MDSpire
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Nonlinear relationship and threshold effect of D-dimer on preoperative deep vein thrombosis in patients with ankle fractures: a retrospective study
Clinical Report: Nonlinear Impact of D-dimer on Preoperative DVT in Ankle Fractures
Overview
This study investigates the association between D-dimer levels and preoperative deep vein thrombosis (DVT) in ankle fracture patients. A nonlinear relationship was identified, with a critical threshold at 3.92 mg/L.
Background
Ankle fractures are common injuries that can lead to serious complications such as deep vein thrombosis (DVT), which poses risks during the perioperative period. D-dimer, a marker of coagulation, has been previously linked to DVT risk, but its specific relationship in ankle fracture patients has not been thoroughly explored.
Data Highlights
Parameter
Value
Patients Included
818
Preoperative DVT Incidence
13.45%
Odds Ratio for D-dimer
1.14 (95% CI: 1.03–1.26, P = 0.010)
Inflection Point for D-dimer
3.92 mg/L
Odds Ratio Below Threshold
1.60 (95% CI: 1.24–2.06, P < 0.001)
Key Findings
D-dimer is an independent risk factor for preoperative DVT in ankle fracture patients.
13.45% of the studied population developed preoperative DVT.
A nonlinear relationship exists between D-dimer levels and DVT risk.
An inflection point for D-dimer was identified at 3.92 mg/L.
Below this threshold, each 1 mg/L increase in D-dimer significantly raised the odds of DVT.
Clinical Implications
Clinicians should consider D-dimer levels when assessing the risk of preoperative DVT in ankle fracture patients. The identified threshold may aid in stratifying patients for appropriate prophylactic measures.
Conclusion
D-dimer levels are associated with preoperative DVT risk in ankle fracture patients.
