Patient-Centered Approach to Surgical Prevention of Ovarian Cancer: A Nonrandomized Clinical Trial - Report - MDSpire

Patient-Centered Approach to Surgical Prevention of Ovarian Cancer: A Nonrandomized Clinical Trial

  • By

  • Karen H. Lu

  • Barbara M. Norquist

  • Gary B. Chisholm

  • Christine B. Peterson

  • Kara C. Long Roche

  • Jamie N. Bakkum-Gamez

  • Iris L. Romero

  • Colleen Feltmate

  • Douglas A. Levine

  • Sarah Kim

  • Andrea R. Hagemann

  • Jeanne Carter

  • Martha Hickey

  • Jamie Crase

  • Kathleen Gavin

  • Deborah Polinsky

  • Alan D. D’Andrea

  • Denise R. Nebgen

  • Elizabeth M. Swisher

  • July 7, 2026

  • 0 min

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Clinical Report: A Patient-Focused Strategy for Surgical Prevention of Ovarian Cancer

Overview

This study evaluates the outcomes of interval salpingectomy with delayed oophorectomy (ISDO) versus risk-reducing salpingo-oophorectomy (RRSO) in high-risk individuals for ovarian cancer.

Background

Ovarian cancer poses a significant risk for individuals with pathogenic variants in genes such as BRCA1 and BRCA2. Current guidelines recommend RRSO as the primary preventive measure, yet many individuals delay surgery, increasing their cancer risk. The introduction of ISDO presents a potential alternative.

Data Highlights

No numerical data was provided in the source material.

Key Findings

  • ISDO aims to reduce ovarian cancer risk while delaying surgical menopause.
  • RRSO is recommended for individuals with P/LP variants, but many delay the procedure.
  • Early menopause can lead to significant health issues.
  • The trial was conducted at nine US cancer centers with ethical considerations regarding randomization.

Clinical Implications

Healthcare providers should consider discussing ISDO as an option for high-risk patients. Understanding patient preferences is crucial in the decision-making process for surgical interventions.

Conclusion

The findings from this study highlight the need for further investigation into surgical prevention of ovarian cancer.

Related Resources & Content

  1. NCCN, National Comprehensive Cancer Network, 2026 -- Guidelines for Genetic Risk Assessment
  2. NCI, National Cancer Institute, 2025 -- PDQ on BRCA1 and BRCA2
  3. NICE, National Institute for Health and Care Excellence, 2024 -- Ovarian Cancer Guidelines
  4. The ASCO Post — Expect Questions About Ovarian Cancer Screening
  5. The ASCO Post — Clinical Trial Participation May Be Associated With Improved Overall Survival in Patients With Ovarian Cancer
  6. The ASCO Post — Clinical Trial Participation May Be Associated With Improved Overall Survival in Patients With Ovarian Cancer
  7. The ASCO Post — Clinical Trial Participation May Be Associated With Improved Overall Survival in Patients With Ovarian Cancer
  8. Expect Questions About Ovarian Cancer Screening
  9. Clinical Trial Participation May Be Associated With Improved Overall Survival in Patients With Ovarian Cancer
  10. https://www.oregon.gov/oha/HPA/DSI-HERC/MembersOnly/3.2b-NCCN-genetics_bopp.pdf
  11. Management of individuals with heterozygous germline pathogenic variants in RAD51C, RAD51D, and BRIP1: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG) - PMC
  12. Recommendations | Ovarian cancer: identifying and managing familial and genetic risk | Guidance | NICE
  13. BRCA1 and BRCA2 (PDQ®) - NCI
  14. Risk-reducing salpingo-oophorectomy: a meta-analysis on impact on ovarian cancer risk and all cause mortality in BRCA 1 and BRCA 2 mutation carriers - PubMed
  15. Breast Cancer Risk and Breast-Cancer-Specific Mortality following Risk-Reducing Salpingo-Oophorectomy in BRCA Carriers: A Systematic Review and Meta-Analysis - PMC
  16. Salpingectomy With Delayed Oophorectomy Versus Salpingo‐Oophorectomy in BRCA1/2 Carriers: Three‐Year Outcomes of a Prospective Preference Trial - PMC
  17. Celebrating Progress in Hereditary Cancer Prevention: The SOROCk Trial - NRG Oncology
  18. Estimands for Effectiveness of Early Salpingectomy to Reduce Ovarian Cancer Risk
  19. Opportunistic Salpingectomy as a Strategy for Epithelial Ovarian Cancer Prevention | ACOG

Original Source(s)

Patient-Centered Approach to Surgical Prevention of Ovarian Cancer: A Nonrandomized Clinical Trial

  • by Karen H. Lu, Barbara M. Norquist, Gary B. Chisholm, Christine B. Peterson, Kara C. Long Roche, Jamie N. Bakkum-Gamez, Iris L. Romero, Colleen Feltmate, Douglas A. Levine, Sarah Kim, Andrea R. Hagemann, Jeanne Carter, Martha Hickey, Jamie Crase, Kathleen Gavin, Deborah Polinsky, Alan D. D’Andrea, Denise R. Nebgen, Elizabeth M. Swisher

  • July 7, 2026

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