Early identification of risk factors for obstructive sleep apnea hypopnea syndrome based on large language models - Report - MDSpire

Early identification of risk factors for obstructive sleep apnea hypopnea syndrome based on large language models

  • By

  • Lei Cheng

  • Juan Bai

  • Aizhu Liu

  • June 15, 2026

  • 0 min

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Clinical Report: Utilizing Large Language Models for Early Detection of OSAHS

Overview

This study presents OSAHSrisk-LLM, a large language model framework designed to identify risk factors associated with obstructive sleep apnea hypopnea syndrome (OSAHS) from patient-generated text. The framework achieved a 92.9% accuracy in classifying text related to OSAHS risk factors, outperforming traditional models.

Background

Obstructive sleep apnea hypopnea syndrome (OSAHS) is a prevalent condition that often goes undiagnosed, leading to significant health risks. Early detection of risk factors is crucial for timely intervention and management. Traditional methods of risk assessment may overlook valuable insights found in unstructured patient narratives, necessitating innovative approaches for effective screening.

Data Highlights

OSAHSrisk-LLM achieved an overall accuracy of 92.9% in identifying OSAHS-related risk factors from patient-generated text.

Key Findings

  • OSAHSrisk-LLM outperformed baseline models including CNN, Text-CNN, Transformer, and BERT.
  • The framework effectively handled highly imbalanced class distributions.
  • It utilized a relevance-aware and ontology-constrained reasoning strategy for text analysis.
  • Standardized clinical terms were used to normalize extracted concepts from informal narratives.
  • Further validation against clinically confirmed OSAHS diagnoses is required for real-world application.

Clinical Implications

The integration of large language models in clinical settings can enhance the early detection of OSAHS by analyzing patient narratives. This approach may improve screening efficiency and facilitate timely interventions, ultimately reducing the burden of undiagnosed OSAHS.

Conclusion

The findings indicate that large language models can significantly aid in identifying OSAHS-related risk factors from unstructured text. Further research is needed to validate these results in clinical practice.

Related Resources & Content

  1. JMIR Medical Informatics, 2026 -- Machine Learning–Based Multidimensional Oximetry for Obstructive Sleep Apnea Screening: Development and External Validation
  2. BMC Psychiatry, 2025 -- Investigating the role of depression in obstructive sleep apnea and predicting risk factors for OSA in depressed patients: machine learning-assisted evidence from NHANES
  3. Frontiers in Digital Health, 2026 -- Assessment of frontier Large Language Models in sleep medicine
  4. npj Digital Medicine, 2025 -- Utilizing Large Language Models to Enhance Diagnosis of Language Disorders Linked to Autism and Recognize Unique Characteristics
  5. AASM Clinical Practice Guideline, 2025 -- Clinical practice guideline for sleep‑disordered breathing in adult nonsurgical inpatients
  6. American College of Cardiology, 2025 -- CPAP May Improve CV Outcomes in High-Risk OSA
  7. PubMed -- Oximetry-based devices in diagnosis of obstructive sleep apnea: A systematic review and meta-analysis
  8. https://aasm.org/wp-content/uploads/2025/02/SDB-Adult-Nonsurgical-Inpatients-CPG.pdf
  9. CPAP May Improve CV Outcomes in High-Risk OSA - American College of Cardiology
  10. Oximetry-based devices in diagnosis of obstructive sleep apnea: A systematic review and meta-analysis - PubMed

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