Topical Recombinant Collagen Following Fractional Radio Frequency Microneedling for Nonsurgical Facelift: Case Report - Report - MDSpire

Topical Recombinant Collagen Following Fractional Radio Frequency Microneedling for Nonsurgical Facelift: Case Report

  • By

  • Thien-Chong Marcus Wong

  • Yizhi Ong

  • June 29, 2026

  • 0 min

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Application of Topical Recombinant Collagen After Fractional Radiofrequency Microneedling

Overview

This case study evaluates the use of topical recombinant collagen following fractional radiofrequency microneedling (FRM) in two patients. Results indicated a reduction in erythema and edema within 1 to 2 hours post-application.

Background

Fractional radiofrequency microneedling is a popular non-invasive treatment for skin tightening and rejuvenation. Patients often experience postprocedural erythema and edema, highlighting the need for effective recovery strategies.

Data Highlights

No numerical data was provided in the article.

Key Findings

  • Topical recombinant collagen was applied immediately post-FRM to two patients.
  • Both patients showed a reduction in facial edema and erythema within 1 to 2 hours post-application.
  • Patients reported relief from skin discomfort and burning sensations after collagen application.
  • No adverse events or side effects were reported during the treatment and recovery period.
  • The treatment was well tolerated, and both patients expressed satisfaction with the recovery results.

Clinical Implications

Further studies are warranted to explore the use of topical recombinant collagen in post-FRM recovery.

Conclusion

This case study highlights the need for further investigation into the use of topical recombinant collagen following fractional radiofrequency microneedling.

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  3. Frontiers in Medicine, Retrospective analysis of the clinical efficacy of topical hyaluronic acid in promoting skin recovery and reducing inflammatory reactions after fractional laser treatment, 2026 -- Title
  4. FDA, Potential Risks with Certain Uses of Radiofrequency (RF) Microneedling – FDA Safety Communication, 2025 -- Title
  5. Effectiveness of Radiofrequency Microneedling in the Treatment of Dermatological Conditions: A Systematic Review, Aesthetic Plastic Surgery, 2026 -- Title
  6. conexiant — AOPT Plus Collagen May Ease Rosacea
  7. Potential Risks with Certain Uses of Radiofrequency (RF) Microneedling – FDA Safety Communication | FDA
  8. Effectiveness of Radiofrequency Microneedling in the Treatment of Dermatological Conditions: A Systematic Review | Aesthetic Plastic Surgery | Springer Nature Link
  9. A Randomized, Double-Blind, Split-Face, Clinical Trial of Angiopoietin-1 Derived Peptide Topical Following Fractional Radiofrequency Microneedling - PubMed

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