Clinical Report: Effective Non-Invasive Treatment of Tricuspid Libman-Sacks Endocarditis

Overview

This case study presents a successful non-surgical management of isolated tricuspid valve Libman-Sacks endocarditis in a pregnant woman with systemic lupus erythematosus and secondary antiphospholipid syndrome. Intensive immunomodulatory therapy and timely anticoagulation led to favorable outcomes, including vegetation regression and the delivery of a healthy infant.

Background

Libman-Sacks endocarditis (LSE) is a rare form of nonbacterial thrombotic endocarditis often associated with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Its occurrence during pregnancy poses significant diagnostic and therapeutic challenges, particularly in patients with severe thrombocytopenia. Understanding effective management strategies is crucial for improving maternal and fetal outcomes in this high-risk population.

Data Highlights

No numerical data available.

Key Findings

Clinical Implications

This case underscores the potential for non-surgical management of isolated tricuspid LSE in pregnant patients through intensive immunomodulatory therapy and careful anticoagulation. Clinicians should consider similar approaches in managing high-risk patients with SLE and APS to optimize maternal and fetal outcomes.

Conclusion

The successful non-invasive treatment of tricuspid LSE in this case highlights the importance of tailored medical management in pregnant patients with complex autoimmune conditions. Further research is warranted to establish standardized treatment protocols.

Related Resources & Content

1. Pediatric Cardiology, 2023 -- Abstracts from the 13th Annual Fetal Cardiology Symposium
2. Pediatric Cardiology, 2022 -- Neonatal Lupus Manifesting as Myocardial Dysfunction
3. Clinical Research in Cardiology, 2025 -- A Case of Newly Diagnosed ALCAPA Syndrome
4. Clinical Rheumatology, 2022 -- Impact of SARS-CoV-2 on Systemic Lupus Erythematosus
5. Libman-Sacks Endocarditis - StatPearls, NCBI Bookshelf
6. EULAR recommendations for the management of antiphospholipid syndrome in adults - PMC
7. 2025 American College of Rheumatology (ACR) Guideline for the Treatment of Systemic Lupus Erythematosus - PubMed
8. Libman-Sacks Endocarditis - StatPearls - NCBI Bookshelf
9. EULAR recommendations for the management of antiphospholipid syndrome in adults - PMC
10. 2025 American College of Rheumatology (ACR) Guideline for the Treatment of Systemic Lupus Erythematosus - PubMed