Current status and research hotspots of pediatric nephrotic syndrome: a bibliometric analysis (2011–2025) - Report - MDSpire

Current status and research hotspots of pediatric nephrotic syndrome: a bibliometric analysis (2011–2025)

  • By

  • Wenyin Yang

  • Yu Pei

  • Chaoyang Wang

  • Mingxia Tang

  • Jiadong Xie

  • Jing Zhao

  • July 9, 2026

  • 0 min

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Clinical Report: Pediatric Nephrotic Syndrome: A Bibliometric Review of Current Trends

Overview

This bibliometric analysis of pediatric nephrotic syndrome (NS) from 2011 to 2025 identifies significant contributions from China and highlights emerging topics such as immunosuppressants and pathogenic mechanisms.

Background

Pediatric nephrotic syndrome is the most prevalent glomerular disease in children, characterized by significant proteinuria and various complications. This bibliometric study aims to provide insights into the evolving landscape of pediatric NS research.

Data Highlights

A total of 2,873 publications from 2011 to 2025 were included in the analysis.

Key Findings

  • China contributed the most articles (452), but its centrality was low (0.01).
  • The institution with the highest number of publications was Assistance Publique Hopitaux Paris, with 77 articles.
  • Author Iijima Kazumoto ranked first with 58 publications.
  • Prominent keywords included 'nephrotic syndrome', 'children', and 'focal segmental glomerulosclerosis'.
  • Emerging clusters of research topics included 'nphs2', 'bone mineral density', and 'glomerulonephritis'.
  • Latest burst keywords were 'leukocyte count', 'lipoid nephrosis', and 'estimated glomerular filtration rate'.

Clinical Implications

This bibliometric analysis presents current trends in pediatric nephrotic syndrome research.

Conclusion

This bibliometric evaluation clarifies the current research status of pediatric nephrotic syndrome and identifies key areas for future investigation.

Related Resources & Content

  1. KDIGO 2025 Clinical Practice Guideline for the Management of Nephrotic Syndrome in Children
  2. IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome
  3. Frontiers in Immunology — From empirical treatment to precision intervention: a multi-database bibliometric analysis of neuropsychiatric systemic lupus erythematosus (2006–2025)
  4. Frontiers in Immunology — Global perspectives on lupus nephritis: a review of clinical trials and therapeutic innovations
  5. Frontiers in Pediatrics — Prenatal NSAIDs exposure and childhood kidney disease: a systematic review and meta-analysis
  6. Drug Safety — Renal Injury Induced by Medications in Preterm Infants: Current Insights and Strategies for Early Identification
  7. KDIGO 2025 Clinical Practice Guideline for the Management of Nephrotic Syndrome in Children
  8. IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome | Pediatric Nephrology | Springer Nature Link
  9. An international, multi-center study evaluated rituximab therapy in childhood steroid-resistant nephrotic syndrome - PubMed
  10. Rituximab in pediatric refractory nephrotic syndrome: a systematic review and meta-analysis evaluating therapeutic efficacy and adverse event profiles | Pediatric Nephrology | Springer Nature Link
  11. Rituximab-associated adverse events in nephrotic syndrome: A systematic review and meta-analysis - ScienceDirect
  12. IPNA consensus definitions for clinical trial outcomes in steroid-resistant nephrotic syndrome | Pediatric Nephrology | Springer Nature Link

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