A multicenter clinical study on transanal endoscopic sphincter-preserving resection of low rectal tumors - Report - MDSpire

A multicenter clinical study on transanal endoscopic sphincter-preserving resection of low rectal tumors

  • By

  • Xiaoke Hu

  • Shuaishuai Fan

  • Jia Xue

  • Hongrui Li

  • Guangya Sun

  • Zeyu Cai

  • Wang Le

  • Ruixue Wang

  • Haiqing Hu

  • June 12, 2026

  • 0 min

Share

Clinical Report: Transanal Endoscopic Sphincter-Sparing Resection for Low Rectal Neoplasms

Overview

This study evaluates the feasibility, safety, and clinical efficacy of Transanal Endoscopic Sphincter-Preserving Resection (TA-ESPR) in patients with low rectal tumors. The findings indicate a 100% en bloc and complete resection rate with a low recurrence rate of 2.7%.

Background

Transanal Endoscopic Sphincter-Preserving Resection (TA-ESPR) is a novel technique aimed at treating low rectal tumors while preserving anal function. Traditional surgical options often lead to significant complications, including permanent stoma formation and fecal incontinence, which can severely impact patients' quality of life. As the issue of overtreatment becomes more apparent, TA-ESPR offers a minimally invasive alternative for patients who decline radical surgery.

Data Highlights

ParameterValue
Patients Enrolled37
Low-Grade Rectal Cancer73%
Neuroendocrine Tumors16.2%
Stromal Tumors10.8%
En Bloc Resection Rate100%
Complete Resection Rate100%
Recurrence Rate2.7%
Mean Follow-Up Duration (months)36.86 ± 16.71

Key Findings

  • TA-ESPR achieved a 100% en bloc resection rate.
  • Complete resection rate was also 100% among the patients studied.
  • The mean follow-up duration was 36.86 months.
  • The recurrence rate post-TA-ESPR was 2.7%.
  • No severe adverse events were reported during the study.
  • 73% of patients had low-grade rectal cancer.

Clinical Implications

TA-ESPR presents a safe and effective treatment option for patients with low rectal tumors, particularly for those with significant comorbidities or those who refuse radical surgery. The technique not only preserves anal function but also enhances postoperative quality of life.

Conclusion

TA-ESPR is a promising ultra-minimally invasive approach for managing low rectal tumors, demonstrating high efficacy and safety in preserving anal function.

Related Resources & Content

  1. International Journal of Colorectal Disease, 2026 -- Early evaluation of the low anterior resection syndrome after sphincter sparing rectal cancer surgery and prompt treatment: a cohort study protocol
  2. Surgical Endoscopy, 2023 -- Preliminary Findings from a Multicenter Phase II Study on Transanal Total Mesorectal Excision for Rectal Cancer
  3. Techniques in Coloproctology, 2024 -- Transanal Surgical Approach for Managing Anastomotic Leakage Following Low Anterior Resection in Rectal Cancer: A Prospective Study
  4. Langenbeck's Archives of Surgery, 2025 -- Robotic Transanal minimally invasive surgery for rectal neoplasms: A systematic review of outcomes and innovations
  5. Localised rectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up - PubMed, 2025
  6. Organ preservation with chemoradiotherapy plus local excision for rectal cancer: 5-year results of the GRECCAR 2 randomised trial - ScienceDirect
  7. Comparison of endoscopic submucosal dissection and transanal endoscopic surgery for the treatment of rectal neoplasia: A systematic review and meta-analysis - PMC
  8. Localised rectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up - PubMed
  9. Organ preservation with chemoradiotherapy plus local excision for rectal cancer: 5-year results of the GRECCAR 2 randomised trial - ScienceDirect
  10. Comparison of endoscopic submucosal dissection and transanal endoscopic surgery for the treatment of rectal neoplasia: A systematic review and meta-analysis - PMC

Original Source(s)

Related Content