Transthoracic echocardiography in children with Staphylococcus aureus bacteraemia: a multi-centre retrospective analysis - Report - MDSpire

Transthoracic echocardiography in children with Staphylococcus aureus bacteraemia: a multi-centre retrospective analysis

  • By

  • Kirsty Gray

  • Farhana Ahad

  • Aubrey Cunnington

  • June 19, 2026

  • 0 min

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Clinical Report: Transthoracic Echocardiography Utilization in Pediatric Patients

Overview

This study evaluated the utilization of transthoracic echocardiography (TTE) in pediatric patients with Staphylococcus aureus bacteraemia (SAB), finding that 5.6% of children undergoing TTE were diagnosed with infective endocarditis (IE), all with established risk factors.

Background

Staphylococcus aureus bacteraemia (SAB) poses a risk for developing infective endocarditis (IE), particularly in children with known risk factors. Understanding the appropriate use of TTE could optimize resource allocation and patient management.

Data Highlights

GroupTTE (n=71)No TTE (n=30)
IE Diagnosed4 (5.6%)0
Median Hospital Stay (days)174
Acute In-Hospital Mortality10
Embolic Phenomena75%1.5%
Persistent Bacteraemia >72 hours67%4.9%
Polymicrobial Growth50%6%

Key Findings

  • 70% of children with SAB underwent TTE.
  • IE was confirmed in 5.6% of children undergoing TTE, all with established risk factors.
  • The TTE group had a significantly longer median hospital stay compared to the no-TTE group (17 vs 4 days).
  • Embolic phenomena were significantly more common in the TTE group (75% vs 1.5%).
  • Persistent bacteraemia at >72 hours was observed in 67% of the TTE group compared to 4.9% in the no-TTE group.
  • Polymicrobial growth on blood culture was found in 50% of the TTE group versus 6% in the no-TTE group.

Clinical Implications

The findings suggest that TTE may be unnecessary in children with SAB who have no established risk factors for IE. A risk-stratified approach could help identify which patients require TTE, potentially reducing unnecessary procedures and hospital stays.

Conclusion

The study advocates for a risk-stratified approach to TTE in pediatric patients with SAB, emphasizing the need for prospective validation before routine changes in practice.

Related Resources & Content

  1. American Heart Association, Professional Heart Daily, 2015 -- Infective Endocarditis in Childhood: 2015 Update
  2. Clinical Infectious Diseases, Oxford Academic, 2024 -- Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children
  3. Clinical Infectious Diseases, Oxford Academic, 2023 -- 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria
  4. Pediatric Cardiology — Assessment of Heart Function in Pediatric Patients Undergoing Liver Transplantation
  5. Pediatric Cardiology — Evaluating the Safety of Transseptal Puncture for Left Atrial Access in Pediatric Patients
  6. Pediatric Cardiology — Comprehensive Cardiac Assessment in Pediatric Patients with Multisystem Inflammatory Syndrome (MIS-C) Post-COVID-19 Using Conventional and Speckle-Tracking Echocardiography
  7. Pediatric Cardiology — Feasibility and Safety of Semi-Supine Exercise Stress Echocardiography in Pediatric and Adolescent Populations
  8. Infective Endocarditis in Childhood: 2015 Update - Professional Heart Daily | American Heart Association
  9. Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children | Clinical Infectious Diseases | Oxford Academic
  10. 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria | Clinical Infectious Diseases | Oxford Academic

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