Clinical Report: Creation and internal assessment of a frailty risk assessment framework
Overview
This study developed and internally validated a model for identifying Fried frailty in older patients with spinal tuberculosis. The frailty prevalence among the studied population was 80.50%.
Background
Frailty is a significant geriatric syndrome associated with adverse outcomes in older adults, including prolonged hospitalization and increased mortality. Spinal tuberculosis, a common form of extrapulmonary TB, poses additional risks for frailty due to chronic inflammatory consumption and malnutrition.
Data Highlights
Variable
Odds Ratio (OR)
95% Confidence Interval (CI)
Age
1.124
1.057–1.196
Non-married status
6.078
2.902–12.730
Number of involved vertebrae
1.278
1.014–1.610
Body Mass Index (BMI)
0.835
0.746–0.934
Barthel Index score
0.956
0.934–0.978
Key Findings
The frailty prevalence among the studied patients was 80.50%.
Age, non-married status, and the number of involved vertebrae were associated with higher odds of frailty.
Higher BMI and Barthel Index scores were linked to lower odds of frailty.
The model achieved an area under the receiver operating characteristic curve of 0.826.
Bootstrap internal validation showed a C-index of 0.826, indicating good model performance.
Clinical Implications
Further validation and prospective studies are necessary to confirm the utility of the developed nomogram in clinical practice.
Conclusion
Further validation of the study's findings is necessary before considering clinical application.
