An Uncommon Instance of Intramuscular Granular Cell Tumor in the Right Thigh: A Case Study and Review of Existing Literature
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By
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Jue Hou
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Yifeng Zheng
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June 23, 2026
Clinical Report: An Uncommon Instance of Intramuscular Granular Cell Tumor
Background
Granular cell tumors are rare soft tissue neoplasms, with GCT of the extremity being particularly infrequent. Accurate diagnosis is crucial as these tumors can be misidentified. Understanding the imaging characteristics and clinical features of GCT-E is essential for effective management.
Data Highlights
| Imaging Modality | Findings |
|---|---|
| Ultrasound | Hypoechoic tumor, 46 × 26 × 35 mm |
| CT | Soft tissue mass in the inferior portion of the vastus medialis |
| MRI | Soft tissue mass with heterogeneous iso-hypointensity on T1WI and heterogeneous hyperintensity on T2WI |
| PET-CT | Elevated FDG uptake |
Key Findings
- GCT-E is an uncommon neoplasm, particularly in the vastus medialis muscle.
- Initial imaging modalities included ultrasound, CT, and MRI, which identified a soft tissue mass.
- PET-CT indicated elevated FDG uptake.
- Histopathological assessment confirmed the diagnosis of an atypical granular cell tumor.
- En bloc resection with negative margins is the standard treatment approach.
- Multimodal imaging aids in delineating the extent of the lesion.
Clinical Implications
The case highlights the importance of multimodal imaging in diagnosing GCT-E and planning surgical interventions. Clinicians should be aware of the potential for misdiagnosis and the necessity of histopathological confirmation.
Conclusion
This case illustrates the rarity of GCT-E and the critical role of imaging in its management. Further studies may enhance understanding and treatment approaches for similar neoplasms.
Related Resources & Content
- Frontiers in Surgery, 2026 -- A Case Study of an Invasive Granular Cell Tumor Arising from the Left Rectus Abdominis Muscle
- Frontiers in Oncology, 2026 -- Case Report: Inflammatory myofibroblastoma of the right forearm in an adult male: a clinical report
- Frontiers in Oncology, 2026 -- Case Report: Granular cell tumor of the axillary tail mimicking node-positive breast carcinoma — two cases with imaging–pathology correlation
- ScienceDirect, 2024 -- Pathogenetic and molecular classifications of soft tissue and bone tumors: A 2024 update
- ESMO, 2020 -- Soft tissue and visceral sarcomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
- Frontiers in Oncology — Granulomatous cutaneous T-cell lymphoma in a patient with atage IVB of mycosis fungoides: a case report and literature review
- Pathogenetic and molecular classifications of soft tissue and bone tumors: A 2024 update - ScienceDirect
- Soft tissue and visceral sarcomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
Based on findings from:
A rare case of intramuscular granular cell tumor in the right thigh: case report and literature review
Jue Hou, Yifeng Zheng. Frontiers In Medicine, 2026.
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1822058/full
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