Clinical and Imaging Characteristics of Severe Mpox: A Case Study Involving 16 Patients from Beijing, China - Report - MDSpire

Clinical and Imaging Characteristics of Severe Mpox: A Case Study Involving 16 Patients from Beijing, China

  • By

  • Fuchun Wang

  • Yuan Fang

  • Zhongkai Zhou

  • Hao Liu

  • Jiahao Ji

  • Lin Jia

  • Han Jia

  • Luyao Zheng

  • Wen Wang

  • Caiping Guo

  • Chunwang Yuan

  • Yue Yin

  • Juming Ma

  • Hongjun Li

  • Budong Chen

  • Junyi Duan

  • Tao Huang

  • Guanghui Zhang

  • Taiyi Jiang

  • Tong Zhang

  • Wei Wang

  • January 20, 2026

  • 0 min

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Clinical Report: Clinical and Imaging Characteristics of Severe Mpox

Overview

This report analyzes the clinical and imaging characteristics of 16 severe mpox cases in Beijing, highlighting the impact of HIV co-infection. The findings underscore the need for early diagnosis and targeted public health interventions.

Background

Mpox, caused by the monkeypox virus, has transitioned from a regional epidemic in Africa to a global health concern, with significant transmission among men who have sex with men (MSM). Severe cases, particularly in immunocompromised individuals, can lead to serious complications and increased mortality. Understanding the clinical and imaging features of severe mpox is crucial for effective management and treatment.

Data Highlights

No numerical data available in the source material.

Key Findings

  • Severe mpox cases often present with disseminated and necrotizing infections affecting multiple organs.
  • High rates of co-infection with HIV were observed, with over half of the patients in the study being HIV-positive.
  • Imaging plays a critical role in diagnosing severe cases and monitoring complications.
  • Classic symptoms include rash, fever, and lymphadenopathy, with severe cases exhibiting pulmonary and gastrointestinal complications.
  • Severe mpox is associated with a significantly increased mortality rate, especially in immunocompromised patients.

Clinical Implications

Healthcare professionals should be vigilant in identifying severe mpox cases, particularly among HIV-positive individuals. Early diagnosis and appropriate imaging can facilitate timely interventions and improve patient outcomes.

Conclusion

The study provides valuable insights into the clinical and imaging characteristics of severe mpox, emphasizing the importance of targeted public health strategies and early intervention in at-risk populations.

References

  1. Hu et al., Clinical management of mpox (monkeypox), 2025 -- WHO Guidelines
  2. NIH, NIH Study Finds Tecovirimat Was Safe but Did Not Improve Mpox Resolution or Pain, 2025 -- NIH
  3. WHO, Broader transmission of mpox due to clade Ib MPXV – Global situation, 2025 -- WHO
  4. Infection — Atypical Transmission of Mpox in a Heterosexual Female: A Case Study
  5. Intensive Care Medicine — Radiological Findings in Patients with Severe COVID-19 Pneumonia
  6. Open Forum Infectious Diseases — Prolonged Mpox PCR Positivity for Over One Year in a Patient with Advanced HIV Infection
  7. The Journal of Infectious Diseases — Transcriptional Analysis of Monkeypox Virus and Immune Responses in Skin Lesion Samples from HIV-Positive Patients
  8. Clinical management of mpox (monkeypox)
  9. NIH Study Finds Tecovirimat Was Safe but Did Not Improve Mpox Resolution or Pain | National Institutes of Health (NIH)
  10. Broader transmission of mpox due to clade Ib MPXV – Global situation

Original Source(s)

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