Comparison of three algorithms to measure breast density on mammograms in a population-based screening cohort - Report - MDSpire

Comparison of three algorithms to measure breast density on mammograms in a population-based screening cohort

  • By

  • Jim Peters

  • Daniëlle van der Waal

  • Carla H. van Gils

  • Mireille J. M. Broeders

  • June 10, 2026

  • 0 min

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Clinical Report: Evaluation of Three Different Algorithms for Assessing Breast Density

Overview

This study evaluates the agreement of three automated algorithms for breast density assessment—Volpara, Quantra, and iCAD—using data from over 61,000 women in a Dutch screening cohort. It also investigates the association between these measurements and breast cancer risk, highlighting the importance of accurate breast density assessment in screening programs.

Background

Breast density is a significant factor influencing mammography performance and breast cancer risk. High breast density can mask tumors, leading to lower sensitivity in mammographic screening. Understanding breast density's role in personalized screening strategies is crucial for improving early detection and reducing breast cancer mortality.

Data Highlights

No numerical data available in the provided material.

Key Findings

  • Three automated algorithms (Volpara, Quantra, iCAD) were compared for breast density assessment.
  • High breast density is linked to increased breast cancer risk and reduced mammographic sensitivity.
  • The study utilized data from over 61,000 women in a Dutch prospective screening cohort.
  • Automated density measurements may enhance consistency compared to traditional visual assessments.
  • Understanding density's impact on screen-detected and interval cancers is essential for screening strategies.

Clinical Implications

Accurate assessment of breast density using automated algorithms can improve screening outcomes by identifying women at higher risk for breast cancer. Tailoring screening intervals and modalities based on individual breast density profiles may enhance early detection efforts.

Conclusion

The findings underscore the need for reliable breast density assessment tools in screening programs to optimize breast cancer detection and improve patient outcomes.

Related Resources & Content

  1. European Radiology, 2026 -- Comparison of three algorithms to measure breast density on mammograms in a population-based screening cohort
  2. European Radiology, 2025 -- Addressing Variations in Breast Density Distribution Across Mammographic Images from Different Manufacturers
  3. European Radiology, 2024 -- Impact of Breast Density on Digital Mammography Sensitivity in a UK Population Study
  4. European Radiology, 2024 -- Evaluation of AI Efficacy Based on Mammographic Density in a Retrospective Analysis of 99,489 Individuals from BreastScreen Norway
  5. ACR Appropriateness Criteria® Female Breast Cancer Screening: 2025 Update - ScienceDirect
  6. European Radiology — Evaluating the Precision of Automated ACR BI-RADS Breast Density Assessment Through Deep Convolutional Neural Networks
  7. ACR Appropriateness Criteria® Female Breast Cancer Screening: 2025 Update - ScienceDirect
  8. Articles Comparison of supplemental breast cancer
  9. Comparison of three algorithms to measure breast density on mammograms in a population-based screening cohort | European Radiology | Springer Nature Link

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