The dual role of metabolic reprogramming in macrophage polarization in rheumatoid arthritis and coronary heart disease and the intervention strategy of traditional Chinese medicine - Report - MDSpire
Advertisement
The dual role of metabolic reprogramming in macrophage polarization in rheumatoid arthritis and coronary heart disease and the intervention strategy of traditional Chinese medicine
Metabolic Reprogramming's Dual Function in Macrophage Polarization
Overview
This review discusses the metabolic reprogramming of macrophages and its dual role in rheumatoid arthritis (RA) and coronary heart disease (CHD).
Background
Macrophage polarization is crucial in the pathogenesis of chronic inflammatory diseases like RA and CHD. The metabolic state of macrophages influences their inflammatory characteristics.
Data Highlights
No numerical data or trial data provided in the source material.
Key Findings
Pro-inflammatory M1 macrophages prefer aerobic glycolysis, while anti-inflammatory M2 macrophages rely on oxidative phosphorylation.
In RA and CHD, the balance of macrophage metabolism is disrupted towards glycolysis.
Metabolic regulators such as Pim2 kinase and phosphoglycerate kinase 1 are involved in macrophage metabolism in RA.
Activation of the PI3K/AKT pathway in CHD promotes glycolytic metabolism in macrophages.
Traditional Chinese medicine compounds like berberine and ginsenoside Rb1 are mentioned in the context of macrophage metabolism.
Clinical Implications
Understanding the metabolic pathways of macrophages in RA and CHD may inform future research directions.
Conclusion
Further exploration of macrophage metabolism in RA and CHD is warranted.
