The predictive value of platelet-to-high density lipoprotein cholesterol ratio and white blood cell-to-mean platelet volume ratio for coronary artery disease risk in STEMI patients - Report - MDSpire
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The predictive value of platelet-to-high density lipoprotein cholesterol ratio and white blood cell-to-mean platelet volume ratio for coronary artery disease risk in STEMI patients
Clinical Report: Evaluating the Prognostic Significance of PHR and WMR in STEMI
Overview
This study evaluates the prognostic value of the platelet-to-HDL cholesterol ratio (PHR) and the white blood cell count to mean platelet volume ratio (WMR) in patients with acute ST-segment elevation myocardial infarction (STEMI). Findings indicate that lower PHR correlates with increased severity and number of coronary lesions, while both ratios serve as predictive markers for STEMI occurrence.
Background
Cardiovascular disease (CVD) remains a leading cause of mortality globally, with acute coronary syndrome (ACS) being a severe manifestation. Identifying reliable prognostic markers for STEMI is crucial for timely intervention and improving patient outcomes. This study investigates the relationship between PHR and WMR with coronary lesion severity in STEMI patients, contributing to the understanding of their clinical significance.
Data Highlights
Measure
STEMI Group
Control Group
P-value
PHR
Higher
Lower
< 0.05
WMR
Higher
Lower
< 0.05
Key Findings
PHR and WMR levels were significantly higher in the STEMI group compared to controls (P < 0.05).
PHR was lower in the multi-vessel group compared to double- and single-vessel groups (P < 0.05).
PHR showed a negative correlation with the number of lesions (r = −0.672, P < 0.001).
Multivariate analysis identified PHR as an independent risk factor for acute STEMI (OR 1.069, P = 0.049).
WMR was a useful predictor specifically for the occurrence of STEMI (AUC = 0.951, P < 0.001).
Clinical Implications
The findings suggest that PHR and WMR can be utilized as adjunctive tools in assessing the risk and severity of coronary artery disease in STEMI patients. Clinicians may consider incorporating these ratios into routine evaluations to enhance risk stratification and guide treatment decisions.
Conclusion
Lower PHR is associated with greater severity and number of coronary lesions in STEMI patients, highlighting its potential as a prognostic marker. Both PHR and WMR are valuable in predicting STEMI occurrence.
