Long-term outcome of patients with atrial fibrillation and heart failure with preserved ejection fraction after combined radiofrequency catheter ablation and left atrial appendage closure - Report - MDSpire
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Long-term outcome of patients with atrial fibrillation and heart failure with preserved ejection fraction after combined radiofrequency catheter ablation and left atrial appendage closure
Long-term Results in Atrial Fibrillation Patients with Heart Failure and Preserved Ejection Fraction Following Combined Radiofrequency Catheter Ablation and Left Atrial Appendage Closure
Overview
This study evaluates the long-term outcomes of combined radiofrequency catheter ablation and left atrial appendage closure (RF + LAAC) in patients with atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF).
Background
Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are prevalent conditions that often coexist, leading to worse clinical outcomes. Patients with both AF and HFpEF face increased risks of stroke.
Data Highlights
Group
HF Rehospitalization
Ischemic Stroke/TIA
Major Bleeding Events
RF + LAAC
-0.56%
4.95%
3.91%
RF Alone
n/a
n/a
n/a
Key Findings
The RF + LAAC group had a procedural complication rate of 5.2%, comparable to 4.2% in the RF group (p = 0.733).
RF + LAAC significantly reduced the risk of ischemic stroke/TIA (ARR=4.95%, HR = 0.096, p = 0.026).
Major bleeding events were significantly lower in the RF + LAAC group (ARR=3.91%, HR = 0.120, p = 0.045).
HF rehospitalization rates were similar between RF + LAAC and RF alone (ARR=0.56%, HR = 1.356, p = 0.690).
Clinical Implications
The findings suggest that RF + LAAC may be a safe and effective treatment option for patients with AF and HFpEF, potentially reducing the risks of ischemic stroke and major bleeding. Clinicians should consider this combined approach in managing such patients.
Conclusion
Combined RF + LAAC was associated with lower risks of ischemic stroke/TIA and major bleeding, without an observed increase in HF rehospitalization, compared with RF alone.
by Qian-ji Che, Yi-Chao Zhang, Mu Chen, Peng-cheng Yao, Qun-Shan Wang, Jian Sun, Wei Li, Bo Liu, Peng-Pai Zhang, Yi-Chi Yu, Yu-li Yang, Mei Yang, Rui Zhang, Yi-Gang Li
