Toward Integrated Models of Infectious Diseases, Harm Reduction, and Primary Care - Report - MDSpire

Toward Integrated Models of Infectious Diseases, Harm Reduction, and Primary Care

  • By

  • Suhanee Mitragotri

  • Aakash Reddy

  • Kevan Shah

  • David T Zhu

  • August 12, 2025

  • 0 min

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Integrated Harm Reduction and Primary Care for Infectious Disease Management

Overview

A pilot program in Chicago integrated primary care and infectious disease services within a harm reduction setting, serving 552 patients primarily with substance use disorders and related infections. The model increased treatment engagement among people who use drugs by leveraging trusted providers and bundling services into a single access point.

Background

People who use drugs (PWUD) often face stigma, structural exclusion, and fear of criminalization that limit access to traditional healthcare. Integrating infectious disease management and primary care within harm reduction programs offers an equity-centered approach to address these barriers. Outreach workers with lived substance use disorder experience play a critical role in building trust and engagement. Despite promising outcomes, resource limitations and regulatory challenges hinder widespread implementation.

Data Highlights

The pilot program in Chicago served 552 patients between 2018 and 2021, focusing on substance use disorders and infections such as hepatitis C and HIV. Integrated care models have been shown to reduce patient attrition, increase engagement, and lower relapse rates in prior studies.

Key Findings

  • Integration of primary care and infectious disease services within harm reduction settings increases treatment engagement among PWUD.
  • Outreach workers with lived experience serve as cultural bridges, fostering trust and improving patient retention.
  • Bundling multiple services into a single access point reduces fragmentation and barriers to care.
  • Resource constraints, stigma, and regulatory hurdles limit scalability of integrated harm reduction programs.
  • Policy reforms including sustainable funding, workforce development, and Medicaid innovations are essential for expansion.
  • New billing codes like CMS Place-of-Service Code 27 for street medicine provide a precedent for reimbursement models supporting integrated care.

Clinical Implications

Clinicians should consider integrated harm reduction models as effective frameworks to engage marginalized PWUD populations in comprehensive care. Supporting multidisciplinary teams including peer outreach workers can enhance trust and treatment adherence. Advocacy for policy changes and sustainable funding is critical to expand access and improve outcomes in this vulnerable group.

Conclusion

The Chicago pilot demonstrates that integrated harm reduction and primary care models can successfully engage PWUD in infectious disease management. Scaling these models requires targeted policy reforms and investment in workforce and infrastructure to ensure sustainable, equitable care delivery.

References

  1. Knodle et al 2021 -- Integrated Primary Care and Infectious Disease Services in Harm Reduction Settings
  2. Prior Evidence -- Impact of Integrated Care Models on Patient Outcomes
  3. Stigma and Workforce Challenges in Harm Reduction Programs
  4. Regulatory Barriers to Syringe Services Programs
  5. Shared-Savings Models for Reimbursement in Integrated Care
  6. National Health Service Corps Loan Repayment Program Expansion
  7. CMS Place-of-Service Code 27 for Street Medicine

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