Sex differences in the predictive value of insulin resistance surrogate indicators for prediabetes among Chinese adults aged 18–45 years: a multicenter cohort study - Report - MDSpire
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Sex differences in the predictive value of insulin resistance surrogate indicators for prediabetes among Chinese adults aged 18–45 years: a multicenter cohort study
Gender-Based Variations in the Predictive Utility of Insulin Resistance Surrogates
Overview
This study evaluates the predictive value of four insulin resistance surrogate indices for incident prediabetes in Chinese adults aged 18 to 45, highlighting significant sex-specific disparities.
Background
The rising prevalence of prediabetes, particularly among younger populations in China, necessitates understanding its predictive markers to enhance early identification and intervention efforts. This study addresses the gap in knowledge regarding sex-specific differences in the predictive utility of insulin resistance surrogates.
Data Highlights
Parameter
Value
Participants
63,795
Incidence of Prediabetes
5,304 (8.31%)
Male Incidence
10.76%
Female Incidence
5.74%
METS-IR HR (Women)
7.82
METS-IR HR (Men)
1.45
TyG-BMI AUC
0.6497
Key Findings
5,304 participants developed prediabetes during the follow-up period.
Men had a significantly higher incidence of prediabetes compared to women (10.76% vs. 5.74%; p< 0.001).
All four insulin resistance indices were independently associated with incident prediabetes.
METS-IR showed a fully adjusted hazard ratio of 7.82 in women compared to 1.45 in men.
TyG-BMI demonstrated the highest predictive accuracy in the overall population with an AUC of 0.6497.
Women exhibited superior discriminative performance across all indices compared to men.
Clinical Implications
The findings indicate sex-specific differences in the predictive utility of insulin resistance surrogate indices.
Conclusion
Insulin resistance surrogate indices demonstrate significant predictive value for prediabetes in young Chinese women compared to men.
Preoperative use was associated with fewer revisions and no increase in short-term complications among patients with obesity, although benefits appeared concentrated in select subgroups.
