Determinants of Acceptance for Tetanus, Diphtheria, and Pertussis (Tdap) Vaccination Among Expectant Mothers: A Cross-Sectional Analysis - Report - MDSpire

Determinants of Acceptance for Tetanus, Diphtheria, and Pertussis (Tdap) Vaccination Among Expectant Mothers: A Cross-Sectional Analysis

  • By

  • Nurhasifah Abd Aziz

  • Nor Afiah Mohd Zulkefli

  • Zainab Hananah Abang Abdullah

  • February 2, 2026

  • 0 min

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Determinants of Acceptance for Tdap Vaccination Among Expectant Mothers

Overview

This study analyzes factors influencing expectant mothers' acceptance of Tdap vaccination. It highlights the importance of clinician recommendations and vaccine accessibility in improving vaccination rates among pregnant women.

Background

Pertussis, tetanus, and diphtheria are serious infectious diseases that pose significant risks, particularly to infants. Maternal immunization with the Tdap vaccine during pregnancy is crucial for providing passive immunity to newborns, thereby reducing the incidence of these diseases. Understanding the determinants of vaccine acceptance among expectant mothers is essential for enhancing immunization strategies and protecting vulnerable populations.

Data Highlights

No numerical data or trial data presented in the article.

Key Findings

  • Maternal Tdap vaccination significantly reduces the incidence of pertussis in infants.
  • Optimal timing for Tdap vaccination is between 27 and 36 weeks of gestation.
  • Expectant mothers' acceptance of Tdap is influenced by clear clinician recommendations.
  • Access to the vaccine is a critical factor in improving vaccination rates among pregnant women.
  • Surveillance data indicate a rise in pertussis cases in Malaysia, emphasizing the need for maternal vaccination.

Clinical Implications

Healthcare providers should prioritize clear communication regarding the benefits of Tdap vaccination during pregnancy. Ensuring easy access to the vaccine can enhance uptake and ultimately protect infants from serious diseases.

Conclusion

Enhancing maternal Tdap vaccination acceptance is vital for safeguarding infants against pertussis, tetanus, and diphtheria. Continued efforts to improve awareness and access are essential for public health.

References

  1. World Health Organization, WHO, 2022 -- Pertussis Statistics
  2. CDC, Guidelines for Vaccinating Pregnant Women, 2026 -- Vaccination Guidelines
  3. Efficacy, Immunogenicity, and Safety of Pertussis Vaccine During Pregnancy: A Meta-Analysis, PubMed, 2025 -- Meta-Analysis
  4. The Journal of Infectious Diseases — The Effect of Pertussis Vaccination During Pregnancy on the Binding Epitopes and Avidity of Anti–Pertussis Toxin Immunoglobulin G Antibodies in Infants and Their Mothers
  5. The Journal of Infectious Diseases — Correction to: Half-life Estimation of Pertussis-Specific Maternal Antibodies in (Pre)Term Infants After In-Pregnancy Tetanus, Diphtheria, Acellular Pertussis Vaccination
  6. The Journal of Infectious Diseases — A Phase 2b Trial Evaluating the Safety, Tolerability, and Immunogenicity of a 6-Valent Group B Streptococcus Vaccine Administered Concomitantly With Tetanus, Diphtheria, and Acellular Pertussis Vaccine in Healthy Nonpregnant Female Individuals
  7. American Journal of Epidemiology — Determining Key Vulnerable Periods for Perinatal Lead Exposure Impacting Vaccine Antibody Levels in Children
  8. CDC Guidelines for Vaccinating Pregnant Women
  9. Efficacy and Safety of Pertussis Vaccine During Pregnancy
  10. Systematic review and meta-analysis of interventions to increase the uptake of vaccines recommended during pregnancy | npj Vaccines

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