Distinctive Liver Function in Individuals with High Myopia: Links to Myopic Macular Degeneration - Report - MDSpire

Distinctive Liver Function in Individuals with High Myopia: Links to Myopic Macular Degeneration

  • By

  • Yujun Pei

  • Jiaqi Meng

  • Wenwen He

  • Keke Zhang

  • Dongling Guo

  • Yi Lu

  • Xiangjia Zhu

  • November 28, 2025

  • 0 min

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Clinical Report: Distinctive Liver Function in Individuals with High Myopia

Overview

This study investigates the relationship between liver function, lipid metabolism, and high myopia, particularly myopic macular degeneration (MMD). Findings suggest a potential liver-eye metabolic axis that may influence the progression of high myopia and its ocular complications.

Background

High myopia is increasingly prevalent and associated with severe ocular complications, including myopic macular degeneration, which can significantly impair vision and quality of life. Understanding the systemic factors, such as liver function and lipid metabolism, that contribute to these complications is crucial for developing effective prevention and management strategies.

Data Highlights

No specific numerical data was provided in the source material.

Key Findings

  • High myopia is defined by an axial length (AL) of the eye ≥ 26 mm.
  • Myopic macular degeneration (MMD) involves structural degeneration of the retina and choroid.
  • Liver function may influence eye health through metabolic and oxidative stress pathways.
  • Altered serum lipid profiles in myopic individuals may reflect systemic metabolic disturbances.
  • Emerging evidence suggests a liver-eye metabolic axis that warrants further investigation.

Clinical Implications

Healthcare professionals should consider the potential impact of liver function and lipid metabolism on the progression of high myopia and MMD. Monitoring these systemic factors may provide insights into patient management and the development of targeted interventions.

Conclusion

The study highlights the need for further research into the associations between liver function, lipid metabolism, and high myopia to better understand their roles in ocular health and disease progression.

References

  1. Unique liver function in high myopia: associations with myopic macular degeneration | BMC Ophthalmology | Springer Nature, 2023 -- Title
  2. Retinal Physician — Diagnosis and Management of Pathologic Myopia, 2019 -- Title
  3. Ophthalmology Management — DIFFERENTIATING MYOPIA AND GLAUCOMA, 2024 -- Title
  4. Retinal Physician — What OCT Reveals About the Fovea, 2012 -- Title
  5. IMI 2025 Digest - Myopia Institute, 2025 -- Title
  6. Pathologic Myopia (Myopic Degeneration) - EyeWiki, 2023 -- Title
  7. Ophthalmology Management — ‘Real world’ OCT: Subtle findings, critical implications
  8. IMI 2025 Digest - Myopia Institute
  9. Pathologic Myopia (Myopic Degeneration) - EyeWiki
  10. Unique liver function in high myopia: associations with myopic macular degeneration | BMC Ophthalmology | Springer Nature Link

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