Stair use and risk of incident rheumatic and non-rheumatic valvular heart disease: a cohort study from the UK biobank - Report - MDSpire

Stair use and risk of incident rheumatic and non-rheumatic valvular heart disease: a cohort study from the UK biobank

  • By

  • Yabing Hou

  • Huichao Wu

  • Hongxi Yang

  • Zuolin Lu

  • June 29, 2026

  • 0 min

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Clinical Report: Association Between Stair Climbing and Valvular Heart Disease

Overview

This study investigates the association between stair climbing and the risk of incident valvular heart disease (VHD) using data from the UK Biobank.

Background

Valvular heart disease (VHD) is a significant global health concern, affecting millions and leading to substantial morbidity and mortality.

Data Highlights

Steps Climbed per DayRisk Reduction for VHD
10–5012%
60–10015%
110–15022%
≥16020%

Key Findings

  • A total of 488,964 participants were included in the study.
  • During a median follow-up of 13.0 years, 17,494 participants (3.6%) developed new-onset VHD.
  • Climbing 10–50, 60–100, 110–150, and ≥160 steps per day was associated with significant reductions in VHD risk.
  • Individuals climbing more than 160 steps daily had a hazard ratio of 0.79 for rheumatic valve disease and 0.78 for non-rheumatic valve disease.
  • Associations were more pronounced in participants with lower levels of total physical activity.

Clinical Implications

Encouraging stair climbing may serve as a simple and effective strategy to reduce the risk of valvular heart disease. Healthcare providers should consider promoting this form of physical activity as part of cardiovascular health recommendations.

Conclusion

The study highlights a significant association between stair climbing and reduced risk of new-onset valvular heart disease.

Related Resources & Content

  1. European Journal of Preventive Cardiology, 2022 -- The contribution of adolescent cardiovascular disease risk factors to vascular stiffness and cardiac remodelling in young adults
  2. Clinical Rheumatology, 2022 -- Validation of Cardiovascular Risk Assessment Tools in Psoriatic Disease: Insights from a UK Biobank Analysis
  3. Clinical Research in Cardiology, 2024 -- Asymptomatic Left Ventricular Impairment in Patients with Rheumatoid Arthritis: Insights from the Porto-RA Prospective Study
  4. 2025 ESC/EACTS Guidelines for the management of valvular heart disease | European Heart Journal | Oxford Academic
  5. 5-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis | JACC
  6. WHO guideline on the prevention and diagnosis of rheumatic fever and rheumatic heart disease
  7. Clinical Rheumatology — Comorbidity Patterns and Disease Features in Patients with Ankylosing Spondylitis: A Cross-Sectional Analysis
  8. 2025 ESC/EACTS Guidelines for the management of valvular heart disease | European Heart Journal | Oxford Academic
  9. 5-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis | JACC
  10. WHO guideline on the prevention and diagnosis of rheumatic fever and rheumatic heart disease

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