Link Between Serum Uric Acid to HDL Cholesterol Ratio and Overall as Well as Cardiovascular Mortality in Gout Patients

By
Xiaolin Lou
Rubing Guo
Yongtong Cao
Wei Zhao
November 19, 2025
0 min

Bmc Cardiovascular Disorders

Overview

This study investigates the relationship between the serum uric acid to HDL cholesterol ratio (UHR) and overall as well as cardiovascular mortality in gout patients. Findings indicate that higher UHR is associated with increased mortality risk, highlighting its potential as a prognostic biomarker in this population.

Background

Gout is a prevalent inflammatory arthritis linked to elevated uric acid levels, which can contribute to cardiovascular disease. Understanding the relationship between UHR and mortality in gout patients is crucial, as it may inform risk assessment and management strategies. Given the rising prevalence of gout, identifying effective biomarkers for mortality risk is essential for improving patient outcomes.

Data Highlights

No specific numerical data or trial results were provided in the source material.

Key Findings

UHR is a promising composite biomarker for assessing cardiovascular risk in gout patients.
Higher UHR is associated with increased all-cause and cardiovascular mortality.
Gout patients are at a heightened risk for cardiovascular events due to systemic inflammation and metabolic dysfunction.
UHR may outperform individual markers like uric acid or HDL cholesterol in predicting coronary artery disease.
Timely intervention for elevated UHR could optimize therapeutic outcomes in gout management.

Clinical Implications

Healthcare professionals should consider UHR as a valuable biomarker for assessing mortality risk in gout patients. Monitoring UHR may facilitate early intervention strategies to mitigate cardiovascular risks associated with gout.

Conclusion

The study underscores the importance of UHR in predicting mortality outcomes in gout patients, suggesting its role as a critical biomarker for clinical assessment and management.