Factors Influencing Disease-Free Survival in Cervical Cancer Patients
Overview
This study evaluates disease-free survival (DFS) in cervical cancer patients at a tertiary care facility in India, identifying key prognostic factors. Significant associations were found between DFS and variables such as age, tumor size, and locoregional spread.
Background
Cervical cancer is a major public health issue in India, with high incidence and mortality rates, particularly due to late-stage diagnoses. Understanding the determinants of DFS is crucial for optimizing treatment and improving long-term outcomes in resource-limited settings. This study contributes to the limited data on survival outcomes in Indian populations, highlighting the need for targeted interventions.
Data Highlights
Variable
DFS Impact
Age ≤50 years
AHR = 1.64; 95% CI: 1.16–2.34
Tumor size ≥4 cm
AHR = 2.98; 95% CI: 1.44–6.15
Vaginal involvement
AHR = 1.56; 95% CI: 1.06–2.29
Lymph node involvement
p=0.012
Addiction status
p=0.023
Key Findings
The median follow-up duration was 23.4 months (IQR: 10.2–52.6).
51.8% of patients were aged ≤50 years, and 68.5% were from rural areas.
Squamous cell carcinoma was the predominant histology, accounting for 91.8% of cases.
DFS showed significant differences based on age, tumor size, vaginal involvement, lymph node involvement, and addiction status.
There was a notable early decline in DFS, indicating higher recurrence risk in the initial years post-treatment.
Clinical Implications
The findings suggest that clinicians should closely monitor younger patients and those with larger tumors or vaginal involvement during the early follow-up period. Enhanced follow-up strategies and targeted interventions may be necessary to address the high recurrence rates observed.
Conclusion
The study highlights the critical role of tumor burden and locoregional spread in influencing DFS in cervical cancer patients. These insights are essential for improving patient management and outcomes in similar healthcare settings.
