Chronological age was not independently associated with ultra-early safety or arrhythmic outcomes after contemporary atrial fibrillation ablation: a real-world single-center study - Report - MDSpire

Chronological age was not independently associated with ultra-early safety or arrhythmic outcomes after contemporary atrial fibrillation ablation: a real-world single-center study

  • By

  • Gennaro De Rosa

  • Marco Giuggia

  • Mattia Peyracchia

  • Martina Peddis

  • Roberto Di Summa

  • Elisa Pelissero

  • Giuseppe Trapani

  • Fabio Ugliano

  • Francesco Fiore

  • Giuseppe Corazzelli

  • Plinio Cirillo

  • Gaetano Senatore

  • July 7, 2026

  • 0 min

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Clinical Report: Age Alone Does Not Predict Safety or Arrhythmic Outcomes

Overview

This study evaluates the impact of age on procedural safety and early arrhythmic outcomes following atrial fibrillation ablation.

Background

Atrial fibrillation (AF) is a prevalent arrhythmia associated with significant morbidity and mortality, particularly in older populations. Transcatheter ablation (TCA) is a key treatment for symptomatic AF, yet the influence of age on its safety and effectiveness remains debated.

Data Highlights

No significant differences in early complications or arrhythmic outcomes were observed across age cutoffs. Age was not independently associated with procedural safety or arrhythmic outcomes.

Key Findings

  • Study analyzed 217 patients undergoing TCA for AF.
  • Mean age of participants was 67 years.
  • No significant differences in complications across age cutoffs (< 65, < 70, < 80 years).
  • Age was not a predictor of procedural safety (OR 0.99; p = 0.812).
  • Age did not predict AF recurrence (OR 1.01; p = 0.77) or persistence (OR 1.00; p = 0.91).

Clinical Implications

These findings suggest that age alone should not be a deterrent for considering TCA in patients with atrial fibrillation. Clinicians may focus on individual patient factors rather than age when assessing procedural risks and benefits.

Conclusion

The study concludes that chronological age does not significantly affect immediate safety or early arrhythmic outcomes in patients undergoing AF ablation.

Related Resources & Content

  1. Clinical Research in Cardiology, 2024 -- Impact of Comorbidity on Mortality and Readmission Rates in Patients with Existing Implantable Pacemakers Undergoing Catheter Ablation: Insights from the German Ablation Registry
  2. Clinical Research in Cardiology, 2020 -- Post-Ablation Sinus Heart Rate and Long-Term Recurrence Risks in Patients with Atrial Fibrillation
  3. Frontiers in Cardiovascular Medicine -- Long-term follow-up of patients with pulmonary hypertension after catheter ablation of atrial fibrillation and atrial tachycardia
  4. Clinical Research in Cardiology — Evaluating Safety and Patient-Reported Outcomes in Initial Versus Repeat Ablation for Atrial Fibrillation: Findings from the German Ablation Registry
  5. 2024 ESC/EACTS Guidelines
  6. Severe Periprocedural Complications After Ablation for Atrial Fibrillation
  7. 26-A-22732-ACC PROGNOSTIC IMPACT OF EARLY RECURRENCE FOLLOWING PULSED FIELD ABLATION: A META-ANALYSIS | JACC
  8. Early Safety Profile Using Pulsed Field Ablation: Prospective Multicenter DISRUPT-AF Study | JACC: Clinical Electrophysiology
  9. Catheter ablation of atrial fibrillation in elderly and very elderly patients: safety, outcomes, and quality of life - PubMed
  10. Insight Into Early Recurrences After Pulsed-Field Ablation for Atrial Fibrillation: Results From a Multicenter Experience - PubMed
  11. ESC 365 - Optimal blanking period following atrial fibrillation catheter ablation: a systematic review and diagnostic meta-analysis of over 28,000 patients
  12. Association Between Diagnosis-to-Ablation Time and Postablation Outcomes in Older Patients With Persistent Atrial Fibrillation | JACC: Advances

Original Source(s)

Chronological age was not independently associated with ultra-early safety or arrhythmic outcomes after contemporary atrial fibrillation ablation: a real-world single-center study

  • by Gennaro De Rosa, Marco Giuggia, Mattia Peyracchia, Martina Peddis, Roberto Di Summa, Elisa Pelissero, Giuseppe Trapani, Fabio Ugliano, Francesco Fiore, Giuseppe Corazzelli, Plinio Cirillo, Gaetano Senatore

  • July 7, 2026

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