Association of advanced therapies for intermediate- to high-risk pulmonary embolism with improved right ventricular function on outpatient follow-up among survivors - Report - MDSpire

Association of advanced therapies for intermediate- to high-risk pulmonary embolism with improved right ventricular function on outpatient follow-up among survivors

  • By

  • Hammad Sheikh

  • Avinash Singh

  • Connor Smith

  • Howard Freeman

  • Abdul Rehman

  • Jeeyune Bahk

  • Sakul

  • Keshav Dixit

  • Alvin Yang

  • Maria Riasat

  • Robert Lookstein

  • Edgar Argulian

  • David J. Steiger

  • June 10, 2026

  • 0 min

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Impact of Advanced Treatment Modalities on Right Ventricular Function

Overview

This study investigates the association between advanced therapies for acute pulmonary embolism (PE) and improvements in right ventricular (RV) function among survivors. Results indicate that advanced treatments are linked to significant echocardiographic enhancements compared to anticoagulation alone.

Background

Pulmonary embolism is a critical condition that can lead to significant morbidity and mortality. The long-term effects of acute PE on right ventricular function are increasingly recognized, necessitating effective treatment strategies. Advanced therapies such as catheter-directed thrombolysis and surgical embolectomy may offer benefits in RV function, which is crucial for patient recovery.

Data Highlights

ParameterAdvanced Therapyp-value
RVOT VTI4.6 cm0.009
RV Ś2.0 cm/s0.006
TR Grade Improvement Odds3.00.002

Key Findings

  • A total of 122 patients were analyzed, with a median age of 64.4 years.
  • Advanced therapies were performed in 17.2% (CDE), 9.0% (CDT), and 9.0% (SPE) of cases.
  • Receipt of any advanced therapy was associated with increased RVOT VTI and RV Ś.
  • Higher odds of TR grade improvement were observed in patients receiving advanced therapies.
  • Findings suggest significant echocardiographic improvements at a median follow-up of 26 weeks.

Clinical Implications

The study highlights the potential benefits of advanced therapies in improving RV function in patients with acute PE. Clinicians should consider these treatment options for appropriate patients to enhance long-term outcomes.

Conclusion

Advanced therapies for acute PE are associated with significant improvements in RV function among survivors. Further prospective studies are needed to confirm these findings.

Related Resources & Content

  1. Clinical Research in Cardiology, 2022 -- Restoration of Right Ventricular Function Following Intermediate-Risk Pulmonary Embolism: Findings from the Multicenter Pulmonary Embolism International Trial (PEITHO)-2
  2. Clinical Research in Cardiology, 2018 -- Delayed echocardiographic recovery at six months as a predictor of long-term outcomes following intermediate-risk pulmonary embolism: Insights from the PEITHO trial post-hoc analysis.
  3. Frontiers in Cardiovascular Medicine, 2026 -- Detected residual venous thrombi and catheter-directed management of intermediate-risk pulmonary thromboembolism
  4. American College of Cardiology, 2026 -- First AHA/ACC acute pulmonary embolism guideline: prompt diagnosis and treatment are key
  5. Intensive Care Medicine — Tailored Approaches for Managing High-Risk Acute Pulmonary Embolism: A Response to the "Catastrophic" Subgroup Discussion
  6. Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism
  7. Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism
  8. Association of advanced therapies for intermediate- to high-risk pulmonary embolism with improved right ventricular function on outpatient follow-up among survivors
  9. First AHA/ACC acute pulmonary embolism guideline: prompt diagnosis and treatment are key - American College of Cardiology

Original Source(s)

Association of advanced therapies for intermediate- to high-risk pulmonary embolism with improved right ventricular function on outpatient follow-up among survivors

  • by Hammad Sheikh, Avinash Singh, Connor Smith, Howard Freeman, Abdul Rehman, Jeeyune Bahk, Sakul, Keshav Dixit, Alvin Yang, Maria Riasat, Robert Lookstein, Edgar Argulian, David J. Steiger

  • June 10, 2026

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