Clinical Report: Impact of Initial Hyperglycemia in Acute Ischemic Stroke

Overview

This study investigates the relationship between admission hyperglycemia and discharge outcomes in acute ischemic stroke patients. It finds that admission hyperglycemia significantly increases the odds of unfavorable discharge outcomes.

Background

Hyperglycemia is prevalent in acute ischemic stroke patients and is linked to poorer outcomes. Understanding its impact on stroke recovery is crucial, especially in regions with high diabetes prevalence. This study aims to clarify the role of hyperglycemia in stroke management and outcomes.

Data Highlights

Key Findings

• Admission hyperglycemia was present in 51.7% of patients.

• It was associated with a tripled adjusted odds of unfavorable discharge outcomes (mRS 3–6).

• Inappropriate glycemic management occurred in 85.8% of hyperglycemic patients.

• Routine HbA1c testing revealed occult diabetes in 18.4% of patients.

• No severe hypoglycemia was reported during the study.

Clinical Implications

The findings indicate a significant association between admission hyperglycemia and unfavorable discharge outcomes.

Conclusion

Admission hyperglycemia significantly impacts discharge outcomes in acute ischemic stroke patients.

Related Resources & Content

1. Wang, Y., et al., 2020 -- Hyperglycemia and Outcomes in Patients with Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

2. Zhang, Y., et al., 2021 -- The Impact of Hyperglycemia on Outcomes in Acute Ischemic Stroke: A Multicenter Study

3. Lee, J., et al., 2020 -- The Relationship Between Admission Hyperglycemia and Stroke Outcomes: A Review

4. Chen, X., et al., 2020 -- Hyperglycemia and Its Impact on Acute Ischemic Stroke: A Review of the Literature

5. AHA/ASA GUIDELINE, 2026 -- 2026 Guideline for the Early Management of Patients with Acute Ischemic Stroke

6. Author(s)/Org, Source, Year -- Title

7. Stroke AHA/ASA GUIDELINE 2026 Guideline for the Ea

8. Stress Hyperglycemia Ratio and Adverse Outcomes in Acute Mild Ischemic Stroke or High-Risk Transient Ischemic Attack: A Secondary Analysis of the INSPIRES Trial - PMC