Clinical Report: A New Nomogram Utilizing Preoperative SIRI in Endometrial Cancer

Overview

This study evaluates the preoperative systemic inflammatory response index (SIRI) as a predictor of lymph node metastasis (LNM) in endometrial cancer (EC) and develops a nomogram combining SIRI with clinicopathological factors for risk assessment.

Background

Endometrial cancer (EC) is a prevalent gynecologic malignancy with rising incidence rates. Accurate preoperative identification of lymph node metastasis (LNM) is crucial for surgical planning and treatment decisions. Existing predictive tools often lack external validation.

Data Highlights

Key Findings

• Preoperative SIRI is an independent predictor of LNM in EC patients.
• The optimal cutoff value for SIRI was determined to be 1.115.
• Multivariate analysis identified age, CA125, histological type, molecular classification, and SIRI as significant predictors of LNM.
• The nomogram integrating these factors outperformed models based on SIRI alone or traditional parameters.
• Marked differences in recurrence-free survival (RFS) and overall survival (OS) were observed between high- and low-risk groups.

Clinical Implications

The nomogram developed in this study provides a tool for preoperative risk stratification in endometrial cancer.

Conclusion

The integration of preoperative SIRI with clinicopathological factors enhances the predictive accuracy for lymph node metastasis in endometrial cancer.

Related Resources & Content

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6. https://www.esgo.org/media/2026/02/PocketGuidelinesA5_EndometrialCarcinoma.pdf
7. Decoding the 2023 FIGO Staging System in Endometrial Cancer: A Practical, Visually Guided Framework for Molecular Risk-Adapted Care Incorporating the 2025 Risk Group Update | Current Oncology Reports | Springer Nature Link
8. Oncologic outcomes of sentinel lymph node mapping in patients with high-intermediate- and high-risk endometrial cancer: a systematic review and meta-analysis - PubMed
9. Role of sentinel node mapping in endometrial cancer in 2025 - PubMed
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12. Molecular subtypes and lymph-node metastasis in endometrial cancer: An updated systematic review and meta-analysis - ScienceDirect
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15. Frontiers | A novel nomogram incorporating preoperative systemic inflammatory response index and clinicopathological parameters for predicting lymph node metastasis in endometrial cancer