Comparison of Nurse-led Interventions and Standard Care on Cardiovascular Risk Factors in Coronary Artery Disease Patients: A Meta-Analysis of Randomized and Observational Studies - Report - MDSpire
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Comparison of Nurse-led Interventions and Standard Care on Cardiovascular Risk Factors in Coronary Artery Disease Patients: A Meta-Analysis of Randomized and Observational Studies

  • By

  • Jing Yang

  • Yun Gao

  • Chao Ping Yu

  • Bo Zhang

  • Li Juan Zou

  • Zhu Yan

  • December 11, 2025

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Clinical Report: Comparison of Nurse-led Interventions and Standard Care on Cardiovascular Risk Factors

Overview

This meta-analysis evaluates the effectiveness of nurse-led interventions compared to standard care in managing cardiovascular risk factors among patients with coronary artery disease (CAD). Findings indicate significant improvements in total cholesterol, LDL, HDL, and systolic blood pressure, alongside enhanced adherence to exercise and smoking cessation.

Background

Coronary artery disease (CAD) remains the leading cause of mortality globally, necessitating effective secondary prevention strategies. Nurse-led interventions have emerged as a promising approach to enhance patient outcomes by addressing modifiable cardiovascular risk factors. This meta-analysis aims to consolidate evidence from various studies to assess the impact of these interventions on CAD patients.

Data Highlights

OutcomeNurse-led InterventionStandard Care
Total CholesterolSignificant ReductionNeutral
LDLSignificant ReductionNeutral
HDLSignificant IncreaseNeutral
Systolic Blood PressureSignificant ReductionNeutral
Adherence to ExerciseHigherLower
Smoking CessationHigherLower

Key Findings

  • Nurse-led interventions significantly reduced total cholesterol and LDL levels.
  • There was a significant increase in HDL levels among patients receiving nurse-led care.
  • Systolic blood pressure was significantly lower in the nurse-led intervention group.
  • Patients in the nurse-led group showed higher adherence to exercise and smoking cessation compared to standard care.
  • Effects on triglycerides, diastolic blood pressure, BMI, and waist circumference were neutral.

Clinical Implications

The findings support the integration of nurse-led interventions in cardiac rehabilitation programs to effectively manage cardiovascular risk factors in CAD patients. Healthcare providers should consider these strategies to enhance patient adherence to lifestyle modifications and medication regimens.

Conclusion

Nurse-led interventions demonstrate significant benefits in managing cardiovascular risk factors among CAD patients, highlighting their importance in secondary prevention strategies. Further implementation of these programs could lead to improved patient outcomes and reduced morbidity.

Related Resources & Content

  1. Yang J, Gao Y, Yu CP, Zhang B, Zou LJ, Yan Z, BMC Cardiovascular Disorders, 2025 -- Nurse-led intervention versus usual care on the cardiovascular risk factors in patients with coronary artery disease: a meta-analysis including data from randomized trials and observational studies
  2. npj Digital Medicine, 2025 -- The effectiveness of eHealth-based cardiovascular disease risk communication: a systematic review and meta-analysis
  3. European Journal of Preventive Cardiology, 2025 -- Effectiveness of coronary heart disease peer support interventions: a systematic review and meta-analysis
  4. Clinical Research in Cardiology, 2020 -- Comparison of Multivessel and Culprit-Only Percutaneous Coronary Intervention in STEMI Patients with Multivessel Disease: A Meta-Analysis of Randomized Trials
  5. What is new in the “2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias”
  6. 2025 AHA/ACC Clinical Performance and Quality Measures for Patients With Chronic Coronary Disease - Professional Heart Daily, American Heart Association
  7. npj Digital Medicine — Comparative Effectiveness of Telemonitoring Approaches in Heart Failure: A Meta-Analysis of Patient Outcomes
  8. What is new in the “2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias”
  9. Nurse-led intervention versus usual care on the cardiovascular risk factors in patients with coronary artery disease: a meta-analysis including data from randomized trials and observational studies | BMC Cardiovascular Disorders | Springer Nature Link
  10. 2025 AHA/ACC Clinical Performance and Quality Measures for Patients With Chronic Coronary Disease - Professional Heart Daily | American Heart Association

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