Development of Arthritis in a Large Real-World Cohort of Patients With Pediatric Onset Psoriasis - Report - MDSpire

Development of Arthritis in a Large Real-World Cohort of Patients With Pediatric Onset Psoriasis

  • By

  • Malak Al-Gawahiri

  • Elke M. G. J. de Jong

  • Ellen J. H. Schatorjé

  • Esther P. A. H. Hoppenreijs

  • Juul M. P. A. van den Reek

  • Marieke M.B. Seyger

  • April 25, 2026

  • 0 min

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Incidence of Arthritis in a Large Cohort of Pediatric Patients Diagnosed with Psoriasis

Overview

This study investigates the incidence of psoriatic arthritis (PsA) in pediatric patients diagnosed with psoriasis, revealing that 2% developed juvenile psoriatic arthritis (JPsA) during a mean follow-up of 5 years.

Background

Psoriasis is a chronic inflammatory skin condition that can lead to psoriatic arthritis, a significant comorbidity. Early identification of psoriatic arthritis in pediatric patients is crucial for effective management.

Data Highlights

No specific numerical data provided in the source material.

Key Findings

  • 2% of pediatric patients with psoriasis developed JPsA during a mean follow-up of 5 years.
  • Older age at first psoriasis diagnosis and presence of uveitis were identified as risk factors for developing JPsA.
  • JPsA accounts for approximately 8% of the juvenile idiopathic arthritis population.
  • Diagnosis of JPsA can be challenging, particularly in patients without psoriatic lesions.
  • Clinical features of JPsA may differ from those of pediatric psoriasis patients who do not develop arthritis.

Clinical Implications

Healthcare providers should be vigilant in monitoring pediatric patients with psoriasis for signs of psoriatic arthritis, particularly in those with identified risk factors. Early referral to a rheumatologist may be warranted for patients exhibiting persistent joint complaints or other concerning symptoms.

Conclusion

The findings underscore the need for increased awareness and early intervention strategies for psoriatic arthritis in pediatric patients with psoriasis.

Related Resources & Content

  1. Frontiers in Pediatrics, 2026 -- Case report : Early-Onset Juvenile Psoriatic Arthritis Presenting at 15 Months: A Diagnostic Challenge in Infancy
  2. Clinical Rheumatology, 2019 -- Ultrasonographic Assessment of Subclinical Synovitis and Enthesitis in Psoriasis Patients and Controls in Saudi Arabia: Two-Year Incidence of Psoriatic Arthritis
  3. Clinical Rheumatology, 2021 -- Absenteeism and Disability Linked to Psoriasis and Psoriatic Arthritis in the United States: A Retrospective Analysis of Claims Data from 2009 to 2020
  4. Development of Arthritis in a Large Real-World Cohort of Patients With Pediatric Onset Psoriasis - PMC
  5. ACR Releases Updated Juvenile Idiopathic Arthritis Guidelines | American College of Rheumatology
  6. Clinical Rheumatology — Comprehensive Analyses from a Large Cohort of Psoriatic Arthritis Patients Support the Integration of a Unified Definition for Peripheral Arthritis Without Subclassification
  7. Development of Arthritis in a Large Real-World Cohort of Patients With Pediatric Onset Psoriasis - PMC
  8. ACR Releases Updated Juvenile Idiopathic Arthritis Guidelines | American College of Rheumatology
  9. Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomised, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial - PMC

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