A higher monocyte-to-lymphocyte ratio is correlated with impaired glomerular function and adverse cardiac remodeling in elderly patients with atrial fibrillation: a retrospective study - Report - MDSpire
Advertisement
A higher monocyte-to-lymphocyte ratio is correlated with impaired glomerular function and adverse cardiac remodeling in elderly patients with atrial fibrillation: a retrospective study
Clinical Report: Elevated Monocyte-to-Lymphocyte Ratio Linked to Diminished Glomerular Function
Overview
This study investigates the association between the monocyte-to-lymphocyte ratio (MLR) and clinical biochemical indexes, as well as cardiac remodeling in elderly patients with atrial fibrillation (AF). High MLR is found to be associated with decreased glomerular function and adverse cardiac remodeling.
Background
Atrial fibrillation (AF) is prevalent among older adults and is linked to increased cardiovascular mortality. Understanding the role of inflammatory markers, such as the monocyte-to-lymphocyte ratio (MLR), in cardiac remodeling and kidney function is crucial for managing the elevated risks associated with AF. This study aims to clarify the relationship between MLR and various health indicators in this population.
Data Highlights
MLR Group
Number of Patients
Low (≤ 0.293)
382
Moderate (> 0.293 to ≤ 0.460)
392
High (> 0.460)
380
Key Findings
High MLR (> 0.460) is associated with male sex.
High MLR correlates with decreased estimated glomerular filtration rate (eGFR).
Lower plasma albumin levels are linked to high MLR.
High MLR is associated with cardiac ventricular dilatation.
High MLR correlates with cardiac dysfunction.
Clinical Implications
The findings indicate that MLR may be associated with cardiovascular and renal health in elderly patients with AF.
Conclusion
The study establishes a link between high MLR and health outcomes in elderly patients with AF.
